Elizabeth Holmes denied request to avoid prison and faces $452 million restitution bill.

Elizabeth Holmes, the founder and CEO of Theranos, has lost her latest bid to avoid prison while she appeals her conviction for wire fraud. The US Court of Appeals for the 9th Circuit denied her motion, ruling that she had not raised a "substantial question" regarding the conduct of her trial. Holmes has been ordered to pay $452 million in restitution to the victims of her crimes, jointly liable with her former lover and top Theranos lieutenant, Ramesh "Sunny" Balwani, who is already in prison after being convicted on a broader range of felonies in a separate trial.