Elizabeth Holmes denied request to stay out of prison during appeal.

Elizabeth Holmes, former CEO of Theranos, has lost her latest bid to avoid prison and has been hit with a $452 million restitution bill. She had been previously ordered to surrender to authorities on April 27 by U.S. District Judge Edward Davila, who sentenced her in November. Holmes is being held jointly liable for that amount with her former lover and top Theranos lieutenant, Ramesh “Sunny" Balwani, who is already in prison after being convicted on a broader range of felonies in a separate trial.