Chiefs' Isiah Pacheco ruled out with shoulder injury against Bills

The Kansas City Chiefs have ruled out four players, including running back Isiah Pacheco and left tackle Donovan Smith, for their upcoming game against the Buffalo Bills. Head coach Andy Reid confirmed that Clyde Edwards-Helaire will be the No. 1 running back, with Deneric Prince being elevated from the practice squad. Linebacker Nick Bolton is expected to be activated from injured reserve. The Bills are relatively healthier, with all their active-roster players listed on the injury report without a game status.