NFL Week 5 Odds: Bears, Rams, and Jaguars Lead Betting Board Amid Injury Turmoil

Key points

• Chicago Bears are road favorites (-2.5) against Green Bay Packers at Lambeau Field.
• Los Angeles Rams are slight favorites (-2.5) over Buffalo Bills in Monday night game.
• Jacksonville Jaguars are favorites (-4.5) against Philadelphia Eagles in London.
• Dallas Cowboys are heavy favorites (-10) against 0-4 Tampa Bay Buccaneers.
• Cincinnati Bengals are road favorites (-7.5) against Miami Dolphins, with total dropping due to injuries.
• Baltimore Ravens are favorites (-3.5) against Atlanta Falcons, but line may move if Lamar Jackson is out.

Background

The 2026 NFL season has seen early volatility, with several teams struggling against the spread. The Buccaneers are 0-4 for the first time in 13 years, while the Eagles are 0-4 ATS. The Bears and Jaguars have shown strong early-season form, with the Bears 3-1 ATS and the Jaguars 3-1 SU and ATS. The Rams and Bills are both 3-1 ATS, setting up a competitive Monday night matchup. The 49ers are 4-0 and 3-1 ATS, facing a 1-1-2 ATS Seahawks team. The Chargers are 0-4 and 0-3-1 ATS, facing a 2-2 ATS Broncos team.

How outlets are covering it

CBS Sports and FOX Sports provide similar early odds, with slight variations in spreads and totals. CBS Sports notes the Bears' line moving from -1.5 to -2.5, while FOX Sports lists the Bears at -3. CBS Sports highlights the Eagles' offensive struggles and the Jaguars' strong margin of victory, while FOX Sports provides updated odds as of October 6. The Buccaneers' official site confirms Jalon Daniels will start in place of injured Baker Mayfield, who is out for at least three games. ESPN's source was inaccessible, so no additional perspectives could be synthesized from that outlet.

Why it matters

Week 5 is a critical juncture for the 2026 NFL season, as early contenders begin to separate from the pack. The Bears' road favorite status at Lambeau Field signals their strong early-season performance, while the Rams' slight favorite status over the Bills suggests a competitive but close matchup. The Eagles' offensive struggles and the Jaguars' strong defense highlight the impact of injuries on betting lines. The Buccaneers' 0-4 record and the Cowboys' heavy favorite status underscore the disparity between the two teams. The potential absence of Lamar Jackson could significantly impact the Ravens-Falcons line, making it a key game to watch.

What to watch

Betting lines for Week 5 may shift as injury updates emerge, particularly for Lamar Jackson and Baker Mayfield. The Eagles-Jaguairs total may drop further if offensive injuries persist. The Ravens-Falcons line could move dramatically if Jackson is out. The Bears-Packers game will be a key test for the Bears' early-season form, while the Bills-Rams game will be a heavyweight matchup. The Buccaneers-Cowboys game will be a test for the Buccaneers' defense and the Cowboys' offense. The Chiefs and Panthers will return from their byes in Week 6, potentially impacting future betting lines.