"Thursday Night Football Showdown: Giants vs. 49ers - Live Updates, Predictions, and Inactives"

The San Francisco 49ers have a chance to start the season 3-0 with a win against the New York Giants, which would be their second 3-0 start in 25 years. The Giants will be without running back Saquon Barkley due to an ankle injury. In the game, Christian McCaffrey tied Jerry Rice's touchdown streak record, Trent Williams and A'Shawn Robinson got into a physical altercation, and the 49ers ultimately won 17-6.