Rapid Spread of JN.1 COVID Variant Raises Concerns

The JN.1 subvariant, derived from the Omicron variant, is rapidly spreading globally and causing about 20% of new COVID-19 infections in the US. It has only one change to its spike protein compared to its predecessor, BA.2.86, but appears to be a faster-moving virus. The rise in JN.1 cases in the US coincides with the holiday travel season and may be due to waning immunity. While the severity of JN.1 infections is not necessarily worse, there has been a decrease in the ability of antibodies to neutralize the subvariant. Only about 18% of US adults have received the latest COVID vaccine round, prompting calls for increased vaccination efforts. The surge in JN.1 cases comes alongside a spike in respiratory illnesses and a 30% increase in COVID-related hospitalizations.