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New Bacterial Defense System Uses Decoy Cyclic Nucleotides to Fight Phages

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Source: Nature
New Bacterial Defense System Uses Decoy Cyclic Nucleotides to Fight Phages
Photo: Nature
TL;DR Summary

A miniature CRISPR–Cas10 enzyme called mCpol produces cyclic di-AMP to inhibit a bacterial toxin, 2TMβ, thereby conferring antiphage immunity through a toxin–antitoxin mechanism that detects phage anti-immunity proteins and prevents cell death during infection.

Topics:health#biology#crispr-cas10#cyclic-di-amp#immune-signalling#phage-defence#toxin-antitoxin
Share this article
  1. A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling  Nature
  2. The Panoptes system uses decoy cyclic nucleotides to defend against phage  Nature
  3. Bacterial Defense Mechanism Identified Using CRISPR-Cas10-Related System with mCpol and 2TMβ  geneonline.com
  4. Panoptes Deploys Decoy Cyclic Nucleotides Against Phages  Bioengineer.org
  5. Phages Use Decoy Cyclic Nucleotides to Evade Bacterial Panoptes Defense System  geneonline.com

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