Advancements in Next-Generation CAR T Cells for Solid Tumor and Hematologic Cancers
TL;DR
Researchers engineered CAR-T cells to secrete bifunctional fusion proteins targeting PD-L1 for localized IL-12 delivery, enhancing antitumor activity and safety in solid tumor models by modulating the tumor microenvironment and reducing systemic toxicity.
Topics:healthmedicine-oncology-immunotherapy#car-t-cells#fusion-proteins#il-12-delivery#medicine-oncology-immunotherapy#pd-l1-targeting#solid-tumors
- Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery Nature
- Multiplex engineering and multifunction T cells for precise and effective immunotherapies Frontiers
- Next-generation CAR T cells could expand solid cancer treatment options Medical Xpress
- Next-Generation CAR T Cells Poised to Transform Solid Tumor Therapies BIOENGINEER.ORG
- Next-Generation CAR T-Cell Therapies Explored in R/R B-Cell Malignancies Targeted Oncology
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