Tag

Solid Tumors

All articles tagged with #solid tumors

health22 days ago•1 min saved

Two Doses of Experimental CAR-T Therapy Erase Liver Cancer in 3-Year-Old

A three-year-old boy with chemo-resistant hepatoblastoma achieved complete cancer remission after receiving two doses of an experimental CAR-T cell therapy. The treatment, which targets the glypican-3 protein, was administered in an outpatient setting without severe side effects. Published in The New England Journal of Medicine, this single-patient case suggests a potential new avenue for treating solid tumors, which have historically resisted CAR-T therapies.

via New York Post|

#car-t-therapy #health #hepatoblastoma

health-and-science28 days ago•3 min saved

Three-Year-Old Achieves Complete Remission of Metastatic Liver Cancer via Experimental CAR T-Cell Therapy

A three-year-old boy with chemotherapy-resistant, metastatic hepatoblastoma achieved complete disease regression after receiving two doses of experimental GPC3-CAR T-cell therapy. Published in The New England Journal of Medicine, the case demonstrates that this immunotherapy can effectively treat solid tumors in an outpatient setting without systemic toxicity. The boy, who had previously undergone surgery and chemotherapy with rapid recurrence, remains disease-free after 12 months. This milestone suggests potential for treating other GPC3-positive solid tumors, though further trials are needed to confirm safety and efficacy across broader populations.

via ScienceAlert|

#car-t-cell-therapy #health-and-science #hepatoblastoma

medicine-oncology-immunotherapy1 year ago•66 min saved

Advancements in Next-Generation CAR T Cells for Solid Tumor and Hematologic Cancers

Researchers engineered CAR-T cells to secrete bifunctional fusion proteins targeting PD-L1 for localized IL-12 delivery, enhancing antitumor activity and safety in solid tumor models by modulating the tumor microenvironment and reducing systemic toxicity.

via Nature|

#car-t-cells #fusion-proteins #il-12-delivery

health2 years ago•1 min saved

"FDA Approves Revolutionary Cell Therapy for Metastatic Melanoma"

The FDA has granted accelerated approval for the first cell therapy, Amtagvi or lifileucel, for treating advanced melanoma, marking a significant milestone in cancer treatment. This immunotherapy, developed by Iovance, involves harvesting cancer-fighting immune cells from the patient's own body. In a phase 2 clinical trial, 31% of patients who had exhausted standard care options responded to the therapy, with 42% of responders still showing positive results after 18 months. Researchers believe this approval could pave the way for similar successes in treating other solid tumors.

via STAT|

#cancer-treatment #cell-therapy #fda

health2 years ago•3 min saved

Harnessing Cancer's Superpower: Engineering Potent T Cells to Kill Tumors

Scientists from UC San Francisco and Northwestern University have developed a new T-cell therapy, called "Judo T-cell therapy," by inserting a mutation found in cancer cells into CAR-T cells, making them 100 times more potent against solid tumors in mice. The researchers have founded a startup, Moonlight Bio, to continue development of this therapy, with lung cancer as their first target for clinical trials within a few years. While concerns about potential risks remain, the team is optimistic about the potential of this approach and plans to continue refining it.

via Freethink|

#cancer #health #mutation

biotech3 years ago•7 min saved

Biotech discovers solid tumor-killing immune cells in patients' blood.

Chicago-based CTRL Therapeutics has raised $10m to develop a new autologous cell therapy that aims to expand beyond the current scope of cancers treated by existing cell therapies and introduce a less complex process for patients and manufacturers. The company is building on another next-generation cell therapy method known as tumor infiltrating lymphocyte, or TIL, therapy, which requires surgically removing cells from the patient’s tumor.

via Endpoints News|

#autologous #biotech #cell-therapy