PFIC’s Hidden Burden: Adult Itching Signals a Rare Liver Disorder

Progressive familial intrahepatic cholestasis (PFIC) can cause severe internal itching in adults, often misdiagnosed because PFIC is treated as a pediatric disorder and imaging may appear normal. Diagnosis relies on symptom patterns and genetic testing to uncover underlying mutations, recognizing PFIC on a spectrum in adults with variable liver function. Awareness, patient advocacy, and resources like the PFIC Network help patients get answers, while treatments such as BYLVAY (odevixibat) offer relief for itch with careful monitoring for side effects and vitamin deficiencies.