CCR5-mutant donor transplant offers HIV remission in Oslo patient
An Oslo man with HIV and bone marrow cancer underwent an allogeneic stem cell transplant from his CCR5Δ32/Δ32 brother. The donor’s double mutation disabled a key HIV entry protein, enabling his new immune system to replace the patient’s. Two years post-transplant, the patient’s HIV is undetectable and he has stopped antiretroviral therapy without viral rebound, indicating a likely cure or sustained remission. The approach is rare, carries significant risks, and findings may guide future cures, but it is not scalable for general HIV treatment and requires further study.