Study: No Severe White Matter Lesions Linked to MDMA Use in Humans
A study published in NeuroImage: Clinical provides evidence that chronic MDMA may not cause white matter lesions that are seen from long-term use of other substances. Results showed increased fractional anisotropy, which suggests increased connectivity, for MDMA users in several brain regions, including the internal capsule, corpus callosum, and frontoparietal white matter. However, there was a negative relationship between fractional anisotropy and frequency of usage in the corpus callosum, suggesting the relationships discovered may be dependent on the frequency and dosage of MDMA use.