New KRAS-Targeting Drug Extends Pancreatic Cancer Survival, FDA Approves Breakthrough Therapy
TL;DR Summary
The FDA has approved daraxonrasib (Rasonque) from Revolution Medicines to treat pancreatic cancer, after a phase 3 trial where patients on the daily pill had a median survival of 13.2 months versus 6.6 months on chemotherapy. The drug targets the mutated KRAS gene, present in more than 90% of pancreatic tumors, potentially altering a historically hard-to-treat cancer. About 67,000 Americans are diagnosed each year, with more than half dying within three months of diagnosis. The FDA granted Breakthrough Therapy designation in 2025.
Topics:business#breakthrough-therapy#fda-approval#health#kras-gene#pancreatic-cancer#targeted-therapy
- FDA approves breakthrough drug daraxonrasib to treat pancreatic cancer BBC
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- FDA Approves Drug for Pancreatic Cancer in Milestone for Treatment of Deadly Disease WSJ
- FDA approves landmark pancreatic cancer drug that's shown to improve survival NPR
- U.S. approves breakthrough pancreatic cancer drug, heralding a new era for an intractable disease Scientific American
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