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Targeted Therapy

All articles tagged with #targeted therapy

New KRAS-Targeting Drug Extends Pancreatic Cancer Survival, FDA Approves Breakthrough Therapy
health8 days ago

New KRAS-Targeting Drug Extends Pancreatic Cancer Survival, FDA Approves Breakthrough Therapy

The FDA has approved daraxonrasib (Rasonque) from Revolution Medicines to treat pancreatic cancer, after a phase 3 trial where patients on the daily pill had a median survival of 13.2 months versus 6.6 months on chemotherapy. The drug targets the mutated KRAS gene, present in more than 90% of pancreatic tumors, potentially altering a historically hard-to-treat cancer. About 67,000 Americans are diagnosed each year, with more than half dying within three months of diagnosis. The FDA granted Breakthrough Therapy designation in 2025.

via BBC|
#breakthrough-therapy#fda-approval#health
Non-smoker with incurable lung cancer defies odds with targeted therapy and brain treatments
health16 days ago

Non-smoker with incurable lung cancer defies odds with targeted therapy and brain treatments

A UK woman, Jade Fardon, diagnosed in 2022 at age 29 with stage IV ALK-positive lung cancer despite never smoking, was treated with a targeted drug that shrank tumors. She later developed brain metastases requiring gamma knife radiotherapy and brain surgery, and after progression she switched to new medication and ongoing monitoring. She remains active in work and fundraising while raising awareness that lung cancer can affect young, non-smokers.

via New York Post|
#alk-positive#brain-metastases#health
Dismissed Cough, Determined Fight: A Young Non-Smoker's Stage 4 Lung Cancer Story
health23 days ago

Dismissed Cough, Determined Fight: A Young Non-Smoker's Stage 4 Lung Cancer Story

Heather Suchan, a non-smoker and mother of two, saw persistent coughs dismissed by doctors before a bronchoscopy confirmed Stage 4 non-small cell lung cancer with an EGFR mutation. After a PET scan revealed widespread disease, she underwent a multi-drug treatment plan including chemotherapy and a targeted drug amivantamab, now administered subcutaneously, which has led to no disease progression and regression of cancer in the liver and bones, allowing her to return to work while continuing treatment.

via TODAY.com|
#egfr-mutation#health#lung-cancer
Non-smoker mom battles stage 4 alk-positive lung cancer and thrives
science1 month ago

Non-smoker mom battles stage 4 alk-positive lung cancer and thrives

A 44-year-old mom with no smoking history develops persistent breathlessness and is diagnosed with stage 4 alk-positive lung cancer. She responds to targeted therapies that block cancer growth, survives years beyond typical expectations, and becomes an advocate for alk-positive patients, highlighting how precision medicine can extend life and improve quality of life.

via Yahoo|
#alk-positive#lung-cancer#non-smoker
Breathless to Breakthrough: A Non-Smoking Mom Defies Stage 4 Lung Cancer
health1 month ago

Breathless to Breakthrough: A Non-Smoking Mom Defies Stage 4 Lung Cancer

Summer Farmen, a 44-year-old Pennsylvania mom with three kids, began experiencing severe breathlessness in early 2020 and was diagnosed with stage 4 alk-positive lung cancer—a rare, non-hereditary mutation highly treatable with targeted therapy. Though prognosis was grim, she has lived more than six years and become a patient advocate through Alk Positive Inc., funding research, leading support programs, and educating others about treatment options and clinical trials while continuing regular scans and treatment.

via Business Insider|
#advocacy#alk-positive#cancer-survivor
Precision drugs extend cancer survival, turning it into a chronic condition
health3 months ago

Precision drugs extend cancer survival, turning it into a chronic condition

Advances in targeted therapies and precision medicine are enabling more people to live with cancer longer, shifting the disease from an imminent death sentence to a chronic condition for many patients. While survival improves across cancers, the era of targeted drugs also highlights ongoing challenges around access, affordability, and managing long-term treatment effects.

via Yahoo|
#cancer#health#healthcare-access
KRAS-Targeting Pill Extends Survival in Metastatic Pancreatic Cancer
science3 months ago

KRAS-Targeting Pill Extends Survival in Metastatic Pancreatic Cancer

A KRAS-targeting pill called daraxonrasib nearly doubles median survival in metastatic pancreatic cancer, boosting it from 6.7 to 13.2 months in a 500-patient randomized trial after prior treatment, with fewer severe side effects; experts say it could become the new standard of care and researchers will study earlier use and KRAS subtypes. FDA expedited review and expanded-access programs are planned, and results were published in NEJM and presented at ASCO.

via ScienceAlert|
#clinical-trial#kras-mutations#pancreatic-cancer
Eye trouble uncovers stage 4 lung cancer; endurance athlete defies odds with new therapies
health4 months ago

Eye trouble uncovers stage 4 lung cancer; endurance athlete defies odds with new therapies

A former Ironman triathlete’s vision problems led doctors to diagnose stage 4 lung cancer, and after a sequence of targeted therapies—including afatinib, osimertinib, and the IV drug amivantamab (Rybrevant)—he has lived seven years beyond an initial 12–24 month prognosis and now raises awareness through advocacy and endurance events.

via Fox News|
#amivantamab#health#lung-cancer
Colorado man first in state to receive pioneering pancreatic cancer drug
health6 months ago

Colorado man first in state to receive pioneering pancreatic cancer drug

A Lafayette father with stage 4 pancreatic cancer is the first patient in Colorado to receive Zenocutuzumab, a newly FDA-approved targeted therapy that targets the tumor's NRG1 gene fusion after chemotherapy stopped working; since starting the drug, he has shown a dramatic response and improved quality of life, illustrating a broader shift toward precision medicine in pancreatic cancer that could extend survival for some patients.

via 9News|
#health#nrg1-gene-fusion#pancreatic-cancer
Lung cancer shifts to younger, non-smoking women
health6 months ago

Lung cancer shifts to younger, non-smoking women

A growing share of lung cancer cases now occur in never-smokers, especially women, with radon exposure and other factors contributing to risk. Laura Hamann’s story illustrates this trend, often asymptomatic and found incidentally; advances in targeted therapies are improving outcomes, and experts urge radon testing and discussion of screening for high-risk individuals.

via KSDK|
#health#lung-cancer#non-smokers