Christina Applegate Reveals 2021 MS Diagnosis Was Wrong, But Symptoms Persist

Emmy-winning actress Christina Applegate disclosed on Tuesday that her 2021 diagnosis of multiple sclerosis (MS) was incorrect. Despite the correction, her debilitating symptoms have worsened, leaving her without a definitive medical explanation. Doctors are currently investigating the true cause of her condition.
Key points
- Applegate announced the misdiagnosis on her podcast 'MeSsy,' hosted with actress Jamie Lynn Sigler.
- Her symptoms, including numbness and balance issues, have persisted or worsened despite the new finding.
- Neurologist Marwa Kaisey noted that MS misdiagnoses are common due to the lack of a single definitive test.
- Applegate described the revelation as a 'mindf**k,' stating she is 'back at square one' regarding her health.
Background
Applegate was diagnosed with MS in 2021, a condition that led to her departure from the Netflix series 'Dead to Me' and the publication of her memoir 'You With the Sad Eyes.' She had been a prominent advocate for MS awareness for five years before this recent development.
How outlets are covering it
The Washington Post and The New York Times focused on Applegate's emotional reaction, highlighting her tears and frustration that her symptoms did not improve. CNN emphasized the broader medical context, noting that nearly 1 in 5 MS diagnoses may be incorrect. All outlets agreed that Applegate's condition remains unexplained and that her doctors are conducting new investigations.
Why it matters
This case highlights the challenges in diagnosing complex neurological conditions and the emotional toll of medical uncertainty. It also underscores the importance of accurate diagnosis in managing chronic health issues, particularly for public figures who advocate for specific diseases.
What to watch
Applegate's medical team is expected to continue investigating the underlying cause of her symptoms. The outcome of this investigation may provide new insights into neurological conditions that mimic MS.
- Christina Applegate says she was misdiagnosed with multiple sclerosis The Washington Post
- ‘Back at Square One’: Christina Applegate Says Her M.S. Was Misdiagnosed The New York Times
- Christina Applegate, a leading MS advocate, says doctors found she doesn’t have the disease after all CNN
- ‘It’s really the exception that it’s not MS.’ A Boston expert explains why Christina Applegate’s misdiagnosis is rare. The Boston Globe
- Christina Applegate Breaks Down in Tears Revealing She Was Misdiagnosed with MS: ‘I’m Back at Square One’ People.com
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