All articles tagged with #multiple sclerosis
Nature Metabolism reports that irisin, a myokine released during exercise, promotes neuronal survival in an inflammation-driven model of multiple sclerosis, suggesting a possible mechanism by which physical activity could modify disease progression.
A Notre Dame team directly compares the CPZ and LPC MS demyelination models using single-cell RNA sequencing and human tissue, showing distinct genetic and cellular footprints and revealing that CPZ better models oligodendrocyte stress/repair while LPC captures immune responses; by matching model lesions to human MS data, the study provides a roadmap for choosing the right preclinical model to pursue remyelination therapies rather than only immune suppression.
Finnish researchers identified two drug molecules that promote remyelination in MS models, suggesting a potential path to repairing nerve damage rather than only reducing inflammation. One drug targets the unfolded protein response in brain cells, while the other alters scar tissue around damaged areas. Both produced strong remyelination and lower neuroinflammation in animal and cell models, but human trials and brain-delivery challenges remain before clinical use.
Terry Wahls, a physician diagnosed with MS, says a paleo-style diet, targeted supplements, exercise, and other lifestyle changes reversed her disability, propelling her into a central role in the functional medicine movement. The piece traces her decline under conventional MS therapies, her self-directed diet-and-lifestyle approach (the Wahls Protocol), and small studies noting fatigue and functional improvements, while noting that larger, rigorous trials are limited and critics warn against overinterpreting limited data or conflating correlation with causation. It also explores the broader commercial and clinical debate over root-cause therapies, microbiome testing, and the balance between innovation and evidence.
Christina Applegate’s former Married... with Children co-stars and other A-listers — including Ed O’Neill and Katey Sagal — reportedly reached out with love and support after her recent hospitalization amid her ongoing multiple sclerosis battle; a source said the friends are anguished but don’t believe she’s dying and wanted to make sure nothing was left unsaid. Applegate, who disclosed an MS diagnosis in 2021, later posted that she’s feeling better every day, though reps haven’t detailed the hospitalization’s cause.
Fernando Mendoza, the No. 1 overall pick by the Las Vegas Raiders, celebrated his draft moment at home with his wheelchair-bound mother after skipping the Pittsburgh ceremony to stay in Florida for easier travel to Las Vegas; the Indiana standout—with Cuban-American roots—has said his family’s support has been central from college to the NFL.
Fernando Mendoza announced the Mendoza Family Fund, in partnership with the National MS Society, to raise over $1 million for multiple sclerosis research over the next three years, including a $500,000 initial donation in honor of his mother Elsa, who has MS; the effort aims to accelerate advances and, as Mendoza put it, help end the disease.
Alan Osmond, the eldest Osmond brother and a key songwriter for hits like One Bad Apple, died at 76 after a long battle with multiple sclerosis, at his Lehi, Utah home with his wife Suzanne and eight sons by his side. A foundational member of the family act that rose to fame in the 1960s–70s, he later helped produce The Donny and Marie Show and transitioned to country music before retiring; Wayne Osmond, his brother, died in 2025. He is survived by his wife, eight sons, 30 grandchildren, five great‑grandchildren, and his siblings, with service plans forthcoming.
Alan Osmond, the eldest member and de facto leader of the 1970s family group the Osmonds, died at 76 in Salt Lake City after a long career that included chart-topping hits and his work as a writer/producer; he battled multiple sclerosis since 1987 and is survived by his wife Suzanne and eight children, with his brother Merrill sharing a heartfelt tribute after Wayne Osmond’s death earlier this year.
Alan Osmond, the eldest Osmond brother and co‑founder of The Osmonds, died at 76 in Utah after a four‑decade battle with multiple sclerosis. Merrill Osmond announced the death, praising his brother’s faith, creativity, and charitable work, including the Children’s Miracle Network Telethon. He is survived by his wife Suzanne, eight sons, 30 grandchildren and five great‑grandchildren; his passing follows the 2025 death of brother Wayne Osmond.
Alan Osmond, the oldest member of The Osmonds and a central figure in turning the family into a worldwide phenomenon, died at about 8:30 p.m. Monday at age 76, surrounded by his wife Suzanne and their eight sons. Diagnosed with multiple sclerosis about 40 years ago, he retired from performing but helped shape the Osmond family's career and co-founded Stadium of Fire in Provo. He contributed hits like One Bad Apple, Crazy Horses, and Are You Up There?, and is survived by his wife, eight sons, 30 grandchildren, five great-grandchildren, and his brothers and sister, Merrill, Jay, Donny, Jimmy, Virl, Tom, and Marie. He had previously spoken of longing to be with his brother again.
Christina Applegate posted on Instagram that she’s getting stronger every day after a recent hospitalization, emphasizing that health issues are a constant in her life but she remains focused on recovery. The actor has publicly discussed her long-held multiple sclerosis diagnosis since 2021, sharing her journey in a memoir and podcast; prior reports of her hospitalization circulated, but she’s signaling improvement and promising to share more soon.
Christina Applegate addressed rumors of a hospital stay with an Instagram post thanking fans and saying she’s focusing on her health and getting stronger, after TMZ reported she was hospitalized. Her rep offered no comment on the hospitalization. Applegate has been openly living with multiple sclerosis since 2021 and has discussed the condition in her memoir You With the Sad Eyes and on podcasts.
Christina Applegate posted a brief health update amid hospitalization rumors, saying health issues related to her long-running battle with multiple sclerosis persist and that she’s focusing on her health while promising to share more soon.
Christina Applegate addressed hospitalization rumors on Instagram, thanking fans and saying health issues persist but she’s getting stronger; a representative didn’t confirm TMZ’s report, and she has been open about living with multiple sclerosis since 2021.