All articles tagged with #multiple sclerosis
Selma Blair revealed at an Anti-Defamation League event that a controversial 2024 Instagram comment led to the total loss of her professional support network, including her agency, manager, and legal representation. Despite a public apology, she described the aftermath as a complete erasure from the industry, though she has since rebuilt a smaller team and is working on new projects.
Researchers have developed a human-induced pluripotent stem cell (iPSC) spheroid model that accurately simulates myelin damage and repair in the central nervous system. This system allows for the study of remyelination processes, including microglial response and oligodendrocyte regeneration, offering a new platform for drug screening in multiple sclerosis.
Christina Applegate posted her first video since a four-month hospital stay, showing off new blonde hair and thanking fans for their support. The actress, who has battled multiple sclerosis since 2021, confirmed she is home and recovering, though she previously noted that her condition has required frequent hospital visits.
Christina Applegate, 54, shared her first video since a four-month hospitalization on September 21, 2026. The clip, posted to Instagram, shows her with new blonde hair and a smile, captioned with a joke about a 'weird spot' on her cheek. The update follows her discharge in August and comes amid her ongoing battle with multiple sclerosis, which she has publicly discussed since her 2021 diagnosis.
Actress Christina Applegate shared a first post-hospitalization video on Instagram, giving fans a glimpse of life outside the months-long hospital stay as she continues her ongoing battle with multiple sclerosis, thanking supporters and expressing that she is getting stronger and focusing on her health and recovery.
Multi-ancestry GWAS of 20,831 MS cases and 729,220 controls identifies 236 non-MHC MS risk variants (including four new loci), constructs a cross-ancestry polygenic score, and, with single-cell data from blood and brain, highlights inhibitory neurons as a main target for MS-related genetic variation and prioritizes 76 candidate causal genes. The STAT3 risk variant associates with cognition and white-matter integrity in people without MS and with higher neurofilament light in MS, suggesting MS susceptibility may reflect reduced CNS resilience to inflammatory challenges.
A multiancestry GWAS meta-analysis (Japan plus EUR, AFR, AMR) totaling about 29,374 MS cases and 1,843,563 controls identifies 22 novel susceptibility loci beyond the MHC region, including a Japanese-specific ETS1-near locus, and refines HLA signals; integrating single-cell and single-nucleus RNA sequencing of PBMCs and brain lesions, plus spatial transcriptomics of subcortical MS lesions, shows MS risk enrichment in CD4+ T helper cells, regulatory T cells and endothelial cells, with spatial and temporal heterogeneity across brain regions. The work highlights the power of diverse populations and multi-omics to illuminate MS genetics.
A small NEJM trial reports that a single intravenous injection of a lentiviral vector instructs the body to generate CAR-T cells in vivo, which then deplete B cells and autoantibodies and correlate with improved motor and cognitive function, reduced fatigue, and lower inflammation in people with multiple sclerosis and other autoimmune diseases over about six months. This supports the concept of in‑vivo CAR-T therapy as a cheaper, faster approach, but efficacy must be confirmed in more participants.
Christina Applegate has been discharged from the hospital and is back home after a nearly four-month stay, with insiders saying she’s doing well as she continues to battle multiple sclerosis; it isn’t clear whether her autoimmune condition led to the hospitalization, her rep did not comment, and she previously shared gratitude for fans’ support on Instagram.
Christina Applegate has returned home after a months-long hospitalization amid her ongoing battle with multiple sclerosis; a Variety source says she’s “all is well” and getting stronger, following public updates she shared on Instagram about her health.
Numan Unees, a 40-year-old from Rotherham, becomes the first Sheffield participant in a global CAR T cell trial for progressive MS; researchers hope the cancer-derived immunotherapy can reset the immune system and stop disability, potentially changing the treatment landscape if safety and efficacy are proven.
Comedian Kylie Vincent, 26, was diagnosed with multiple sclerosis after a hospital visit prompted by numbness following a Sundance trip. She turned the experience into viral standup, performing about her diagnosis and developing an hourlong show called Lesion Lady, while navigating treatment delays and highlighting challenges in the U.S. healthcare system, with plans for a documentary.
England’s NHS is rolling out fampridine, a twice-daily drug designed to improve walking in people with multiple sclerosis. It is the first MS treatment aimed at walking difficulties, with about 5,000 people expected to be eligible in the first year. Patients will try the drug for 2–4 weeks; those who show improvement can continue long-term. Trials show walking speed improves in around 43% of patients, helping mobility for those with EDSS scores from 4 to 7 and potentially enabling more independence. The MS Society welcomed the move and urged strong MS services to ensure broad access.
The NHS in England will provide fampridine, the first MS treatment shown to improve walking for some patients, potentially helping up to about 5,000 people per year. Eligibility depends on the degree of walking difficulty, and patients will undergo a one-month trial to confirm clear benefit before continuing.
A Science Translational Medicine study reveals how Epstein-Barr virus triggers immune responses that contribute to inflammation and nervous system damage in multiple sclerosis, a finding that could lead to vaccines or antiviral therapies tailored to MS with fewer side effects than current immunosuppressants.