All articles tagged with #multiple sclerosis
Christina Applegate has been discharged from the hospital and is back home after a nearly four-month stay, with insiders saying she’s doing well as she continues to battle multiple sclerosis; it isn’t clear whether her autoimmune condition led to the hospitalization, her rep did not comment, and she previously shared gratitude for fans’ support on Instagram.
Christina Applegate has returned home after a months-long hospitalization amid her ongoing battle with multiple sclerosis; a Variety source says she’s “all is well” and getting stronger, following public updates she shared on Instagram about her health.
Numan Unees, a 40-year-old from Rotherham, becomes the first Sheffield participant in a global CAR T cell trial for progressive MS; researchers hope the cancer-derived immunotherapy can reset the immune system and stop disability, potentially changing the treatment landscape if safety and efficacy are proven.
Comedian Kylie Vincent, 26, was diagnosed with multiple sclerosis after a hospital visit prompted by numbness following a Sundance trip. She turned the experience into viral standup, performing about her diagnosis and developing an hourlong show called Lesion Lady, while navigating treatment delays and highlighting challenges in the U.S. healthcare system, with plans for a documentary.
England’s NHS is rolling out fampridine, a twice-daily drug designed to improve walking in people with multiple sclerosis. It is the first MS treatment aimed at walking difficulties, with about 5,000 people expected to be eligible in the first year. Patients will try the drug for 2–4 weeks; those who show improvement can continue long-term. Trials show walking speed improves in around 43% of patients, helping mobility for those with EDSS scores from 4 to 7 and potentially enabling more independence. The MS Society welcomed the move and urged strong MS services to ensure broad access.
The NHS in England will provide fampridine, the first MS treatment shown to improve walking for some patients, potentially helping up to about 5,000 people per year. Eligibility depends on the degree of walking difficulty, and patients will undergo a one-month trial to confirm clear benefit before continuing.
A Science Translational Medicine study reveals how Epstein-Barr virus triggers immune responses that contribute to inflammation and nervous system damage in multiple sclerosis, a finding that could lead to vaccines or antiviral therapies tailored to MS with fewer side effects than current immunosuppressants.
New research shows Epstein–Barr virus activates CD4+ T cells that attack nerve insulation in multiple sclerosis, and that anti-CD20 therapies (which reduce B cells and viral stimuli) lower CD4+ T-cell responses and EBV activity—hinting immunotherapies could slow relapses and progression.
Janice Dean, a longtime Fox News meteorologist on Fox & Friends, announced she is stepping away after 22 years because her multiple sclerosis has progressed and the demanding early-morning schedule is no longer sustainable; doctors advised stepping back, and she shared a farewell message thanking viewers for their support.
A mouse study found the anti-aging drug combo dasatinib plus quercetin (D+Q) caused dramatic myelin loss in the brain, with younger mice more affected and the corpus callosum deteriorating. Damaged oligodendrocytes appeared to revert to a juvenile, less functional state resembling cells seen in multiple sclerosis, offering new MS clues while highlighting potential brain risks of senolytic therapies and cautioning off-label use.
Nature Metabolism reports that irisin, a myokine released during exercise, promotes neuronal survival in an inflammation-driven model of multiple sclerosis, suggesting a possible mechanism by which physical activity could modify disease progression.
A Notre Dame team directly compares the CPZ and LPC MS demyelination models using single-cell RNA sequencing and human tissue, showing distinct genetic and cellular footprints and revealing that CPZ better models oligodendrocyte stress/repair while LPC captures immune responses; by matching model lesions to human MS data, the study provides a roadmap for choosing the right preclinical model to pursue remyelination therapies rather than only immune suppression.
Finnish researchers identified two drug molecules that promote remyelination in MS models, suggesting a potential path to repairing nerve damage rather than only reducing inflammation. One drug targets the unfolded protein response in brain cells, while the other alters scar tissue around damaged areas. Both produced strong remyelination and lower neuroinflammation in animal and cell models, but human trials and brain-delivery challenges remain before clinical use.
Terry Wahls, a physician diagnosed with MS, says a paleo-style diet, targeted supplements, exercise, and other lifestyle changes reversed her disability, propelling her into a central role in the functional medicine movement. The piece traces her decline under conventional MS therapies, her self-directed diet-and-lifestyle approach (the Wahls Protocol), and small studies noting fatigue and functional improvements, while noting that larger, rigorous trials are limited and critics warn against overinterpreting limited data or conflating correlation with causation. It also explores the broader commercial and clinical debate over root-cause therapies, microbiome testing, and the balance between innovation and evidence.
Christina Applegate’s former Married... with Children co-stars and other A-listers — including Ed O’Neill and Katey Sagal — reportedly reached out with love and support after her recent hospitalization amid her ongoing multiple sclerosis battle; a source said the friends are anguished but don’t believe she’s dying and wanted to make sure nothing was left unsaid. Applegate, who disclosed an MS diagnosis in 2021, later posted that she’s feeling better every day, though reps haven’t detailed the hospitalization’s cause.