"Study Finds First-Degree Relatives 9 Times More Likely to Develop Severe Depression"

A new study found that close relatives of individuals with treatment-resistant depression (TRD) are nine times more likely to develop TRD themselves, as well as other psychiatric conditions and a higher risk of suicide. The study, based on national health insurance data from Taiwan, suggests a genetic transmission of TRD across families and highlights the need for early consideration of alternative treatments when standard antidepressant therapy fails, especially for those with a family history of TRD.