High-Dose DHA Fails to Boost Cognition or Prevent Dementia in At-Risk Adults

A randomized, double-blind trial found that two years of high-dose DHA supplementation raised brain and blood DHA levels in older adults at risk for dementia, but it did not improve cognitive function or brain structure compared with placebo, even among APOE ε4 carriers. The study suggests DHA alone does not prevent dementia, though omega-3s remain beneficial as part of a balanced diet and brain-healthy lifestyle.