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KRAS-ERK switch could revive chemotherapy response in pancreatic cancer

1 min read
Source: SciTechDaily
KRAS-ERK switch could revive chemotherapy response in pancreatic cancer
Photo: SciTechDaily
TL;DR

Researchers identify a KRAS/ERK/JUNB signaling axis that suppresses the differentiation regulator GATA6, pushing pancreatic tumors from a classical, chemo‑sensitive state to a basal, chemo‑resistant one; inhibiting this pathway raises GATA6 levels, reverting cells to a more treatable state and enhancing the effectiveness of standard chemotherapy when paired with targeted therapies.

Topics:health#chemotherapy-resistance#erk#gata6#health#kras#pancreatic-cancer
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  1. Breakthrough Discovery Could Make Pancreatic Cancer Respond to Chemo Again  SciTechDaily
  2. Scientists find the genetic switch that makes pancreatic cancer resist chemotherapy  ScienceDaily
  3. Melvin Sanicas: How GATA6 Levels Influence Treatment Response in Pancreatic Cancer  Oncodaily
  4. A graphical abstract of the paper’s findings (IMAGE)  EurekAlert!
  5. Scientists uncover molecular ‘switch’ that could make pancreatic cancer more treatable  Asia Research News |

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