Massive IBS Drug Study Finds Small Mortality Rise With Some Treatments

A large, nearly 20-year study of 650,000+ US adults with IBS linked long-term antidepressant use to about a 35% higher risk of death and showed the anti-diarrheal drugs loperamide and diphenoxylate associated with roughly double the risk, though the study notes it shows association, not causation, and the overall individual risk remains low; findings prompt personalized treatment and more long-term safety research.