NF1-Associated Cherry Angiomas Map a Vascular Tumor Mechanism

Prospective study finds cherry angiomas are much more common in NF1 patients (48%) than controls (18%), with somatic second hits in NF1 predominantly in endothelial cells and telocytes, supporting a model where biallelic NF1 loss drives these vascular lesions; co-occurring GNAQ variants and UV mutagenesis suggest a shared origin and broader NF1-related vasculopathy.