medicine8.82 min read
Melatonin May Help Ease Chronic Musculoskeletal Pain
10 days ago•Source: Sci.News
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3.25 min•10 days ago
PSA Alone Can Miss Prostate Cancer Growth; Regular Imaging Urged
In two major trials of enzalutamide for advanced prostate cancer, up to about 25% of patients showed radiographic progression on imaging despite stable or undetectable PSA levels, correlating with worse survival. The findings suggest PSA monitoring alone may miss disease growth, underscoring the value of periodic imaging—especially in the first two years—and may prompt updates to clinical guidelines. Possible mechanisms include tumors evolving to grow independent of androgen receptor signaling through lineage plasticity or neuroendocrine transformation.
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Living patient bridged by a gene-edited pig liver ahead of human transplant
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Pomegranate Leaves Yield Molecule That Dismantles TTR Amyloid Fibrils
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Selective CAR-T targets IGHV4-34, sparing healthy immunity in lymphoma mice
A CART4-34 CAR-T therapy targets the IGHV4-34 gene in B-cell cancer, destroying lymphoma cells in mice as effectively as CD19 CAR-T while sparing healthy B cells and avoiding immune suppression; the approach could also be used to treat autoimmune conditions such as lupus, but human trials are needed.
Fibroblast Niches Drive Crohn’s Fistula Formation
This study uses spatial transcriptomics and single-cell analysis to uncover how specialized fibroblast niches, particularly FAS cells, contribute to the formation, progression, and persistence of Crohn's fistulae, highlighting their roles in tissue remodeling, immune regulation, and epithelial regeneration, with implications for targeted therapies.
VEXAS Syndrome: UBA1 Mutations Drive Inflammation and Myeloid Bias
The study investigates how UBA1 mutations in VEXAS syndrome lead to inflammation and myeloid cell bias, revealing mechanisms involving aberrant cell death and ubiquitin pathway defects, and suggesting potential therapeutic targets.
mRNA COVID Vaccines Enhance Cancer Immunotherapy Effectiveness
COVID-19 mRNA vaccines enhance the effectiveness of immune checkpoint inhibitors in cancer treatment by stimulating innate and adaptive immune responses, increasing tumor PD-L1 expression, and potentially restoring immune sensitivity in 'cold' tumors, leading to improved survival outcomes in patients with NSCLC and melanoma.
Innovative Multi-Omics and Mapping Techniques Enhance Lung Cancer Treatment Predictions
This study develops spatial multi-omics and machine learning-based biomarkers to predict immunotherapy outcomes in advanced non-small cell lung cancer, highlighting the roles of immune cell spatial organization, macrophage PD-L1 expression, and gene signatures in resistance and response, validated across multiple cohorts.
Dana-Farber Develops AI-Powered Tool for Rapid Leukemia Classification
The article presents a rapid epigenomic classification method for acute leukemia using nanopore sequencing and machine learning, based on a comprehensive DNA methylation reference cohort, enabling faster and more precise diagnosis that can complement traditional diagnostic workflows.
Advances in Blood Pressure Regulation Post-Spinal Cord Injury Using ONWARD ARC-IM Therapy
The article investigates the neuronal basis of autonomic dysreflexia after spinal cord injury, identifying specific neuronal subpopulations and their reorganization that trigger this life-threatening condition, and explores therapeutic strategies like electrical stimulation to modulate these neural circuits.
Bariatric Surgery Outperforms GLP-1 Medications for Long-Term Diabetes and Obesity Outcomes
This study compares the macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity, highlighting the potential benefits and data sharing protocols, with references to related research and long-term outcomes.
Advances and Challenges in NAD+ Therapy for Longevity and Well-being
The article reviews emerging strategies, applications, and challenges of targeting NAD+ metabolism in clinical settings, highlighting its potential in treating age-related diseases, neurodegenerative disorders, and cancer, while discussing current research and therapeutic prospects.
Oestradiol's Role in Preventing Ferroptosis and Kidney Injury
The study reveals that female kidney tissues are resistant to ferroptosis and acute kidney injury due to the protective effects of oestradiol, which acts through non-genomic antioxidant mechanisms and ESR1-dependent pathways, while male tissues are more susceptible due to higher ether lipid plasticity and lower hydropersulfide levels.