medicine6.535 min read
Living patient bridged by a gene-edited pig liver ahead of human transplant
1 month ago•Source: Nature
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6.235 min•1 month ago
Pomegranate Leaves Yield Molecule That Dismantles TTR Amyloid Fibrils
Researchers at Kumamoto University identified 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from pomegranate leaves and branches that selectively dismantles preexisting transthyretin (TTR) amyloid fibrils in vitro, in vivo, and with patient-derived fibrils ex vivo, reducing deposits and improving healthspan and lifespan in a C. elegans model. Unlike amyloid-β, PGG targets TTR aggregates specifically, suggesting a promising natural lead for treating TTR amyloidosis, though safety and efficacy in humans remain to be established.
5.005 min•2 months ago
Selective CAR-T targets IGHV4-34, sparing healthy immunity in lymphoma mice
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Advances in Blood Pressure Regulation Post-Spinal Cord Injury Using ONWARD ARC-IM Therapy
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"Breakthrough Gene Therapy Offers Hope for Hereditary Angioedema"
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