Pomegranate Leaves Yield Molecule That Dismantles TTR Amyloid Fibrils
TL;DR
Researchers at Kumamoto University identified 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from pomegranate leaves and branches that selectively dismantles preexisting transthyretin (TTR) amyloid fibrils in vitro, in vivo, and with patient-derived fibrils ex vivo, reducing deposits and improving healthspan and lifespan in a C. elegans model. Unlike amyloid-β, PGG targets TTR aggregates specifically, suggesting a promising natural lead for treating TTR amyloidosis, though safety and efficacy in humans remain to be established.
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- Pomegranate Leaf-Derived Natural Compound Inhibits Disease-Causing Amyloid Formation Bioengineer.org
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