Manchineel: The Caribbean 'Tree of Death' That Blisters Skin, Blinds, and Kills

TL;DR Summary
The Manchineel, native to the Caribbean and nearby regions, is nicknamed the 'Tree of Death' because every part of it contains potent toxins; rain can blister skin, sap can burn eyes causing temporary blindness, and its small apple-like fruits can be deadly (one apple reportedly enough to kill 20 people), prompting warnings marked by red crosses to keep people away.
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