Astrocyte Dysfunction Linked to Memory Impairment and Cognitive Decline.

Astrocyte dysfunction, caused by protein build-up in the cells, may be a driver of cognitive decline and memory loss in those with dementia, according to a preclinical study by Weill Cornell Medicine investigators. The study found that astrocytes can cause cognitive decline through their antiviral activities, which can make neurons hyperactive. The discovery could lead to new treatments that reduce excess immune activity in astrocytes and their detrimental effects on other brain cells and cognition.