Breakthrough in Brain Circuitry Offers Hope for Stress and Depression Treatment
TL;DR
Researchers at UCSF have discovered a brain circuit involving the amygdala and hippocampus that predicts resilience to stress in mice. Disruption in this circuit impairs reward-seeking behavior, but stimulating it using chemogenetics restores resilience and normal behavior. This finding could lead to new non-invasive treatments for chronic stress and depression in humans, as researchers explore similar patterns in human brains.
- Newly Discovered Brain Circuit Predicts Response to Stress Neuroscience News
- Understanding the neural code of stress to control anhedonia Nature.com
- Brain signature linked to resilience in mice suggests a new way of treating severe depression Medical Xpress
- Scientists discover the key to treating depression and anxiety The Brighter Side of News
- Stress can dull our capacity for joy: mouse brain patterns hint at why Nature.com
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