Predicting Mania Risk in Bipolar Spectrum Disorders Using Neurobehavioral Profiles and Polygenic Signatures

A recent study has identified neurobehavioral profiles that can predict the risk of future mania or hypomania in bipolar spectrum disorders (BSD). The study found three profiles: healthy, moderate risk, and high risk, based on factors such as reward sensitivity, impulsivity, and sleep-circadian characteristics. Individuals in the high-risk and moderate-risk groups showed more symptoms of mania over a 12-month period compared to those in the healthy group. The findings may help detect mania risk earlier and inform intervention strategies.