Genetic study links early sexual debut to faster aging and frailty

A large Mendelian randomization analysis using UK Biobank data finds that genetic predisposition to earlier age at first sex is associated with shorter lifespans and greater late-life frailty, via pathways including physical frailty, depression, COPD, and ADHD; findings support targeted education and midlife health screening, but are mostly based on European ancestry and may reflect statistical artifacts, necessitating replication in diverse populations.