AI-guided discovery: Avl9 acts as an off switch for Arf1, redefining cellular transport and cancer links

Using AlphaFold, Cornell researchers identified Avl9 as an off switch that suppresses Arf1 to regulate intracellular protein trafficking. This reveals a broader DENN-domain–protein system controlling cellular transport, with implications for cancer cell movement and tumor progression, and demonstrates AI’s power to accelerate exploratory biology.