Tag

Alphafold

All articles tagged with #alphafold

science1 day ago•2 min saved

Autism drug discovery could hinge on protein interaction maps

UCSF researchers built a molecular map linking 100 autism-risk genes to about 1,800 protein interactions, most previously unreported, and used AlphaFold to pinpoint direct connections. They found a FOXP1-FOXP4 interaction that drives autism-like traits in human organoids, suggesting a new drug-discovery blueprint—targeting protein networks rather than genes alone—to identify potential therapies, with potential pathways for industry collaboration.

via Fierce Biotech|

#alphafold #autism #drug-discovery

science19 days ago•6 min saved

GenAI Hallucinations Could Mislead Biotech Discoveries, Researchers Warn

Generative AI can speed up biology research and drug screening, but it can also generate plausible yet false biological signals. Experts say AI outputs should be treated as testable ideas or synthetic data rather than definitive findings, and must be independently verified in real experiments. The risk varies by use, with cases like AlphaFold 3 illustrating how AI errors can distort evidence if not carefully checked.

via ScienceAlert|

#ai-hallucination #alphafold #biology

artificial-intelligence23 days ago•15 min saved

Hassabis Poised to Swap CEO Desk for Scientist Role as Alphabet Reshapes AI Leadership

An anonymously sourced Semafor report says Demis Hassabis has been planning to step down as Google DeepMind CEO for about a year to become Alphabet’s chief scientist, while remaining DeepMind chair and heading Alphabet’s AI drug‑discovery arm Isomorphic Labs. Alphabet confirmed a broader leadership shakeup to sharpen its AI strategy, with Hassabis continuing to influence DeepMind’s and AlphaFold’s ecosystem.

via Gizmodo|

#alphabet-inc #alphafold #artificial-intelligence

technology1 month ago•2 min saved

Google Ditches AlphaFold, Bets Big on Gemini

Google is dismantling the Nobel-winning AlphaFold team, reassigning most researchers to Gemini-focused projects and Alphabet's Isomorphic Labs, with some members leaving for Anthropic, signaling a strategic shift to invest more resources in Gemini and related drug-discovery initiatives.

via Engadget|

#alphafold #deepmind #gemini

technology1 month ago•5 min saved

DeepMind pivots away from AlphaFold to Gemini-powered science AI

Google DeepMind has dismantled the AlphaFold team as it shifts strategy toward Gemini-powered AI to assist and automate scientific discovery, reassigning most AlphaFold researchers to projects in enzyme design, genomics, nuclear fusion and Isomorphic Labs; several core AlphaFold authors have left, including moves to Anthropic, reflecting a broader industry push to frontier AI systems beyond single science challenges.

via Financial Times|

#alphafold #artificial-intelligence #deepmind

science1 month ago•13 min saved

AlphaFold Opens a Free Global Library of Protein Shapes

AI-powered AlphaFold2 transformed protein folding by predicting 3D structures from sequence in minutes, leading to a public database with roughly 214 million predicted protein structures available for free. Most entries are highly accurate or confidently useful, but about a fifth have low confidence and users should filter by pLDDT. The data is CC-BY-4.0 licensed and widely used, enabling rapid research while raising questions about openness for future commercial tools and the handling of multiple conformations and disordered regions. Ongoing updates include isoforms and alignments; methods like AF-Cluster have had mixed results in extracting alternative conformations.

via Space Daily|

#alphafold #bioinformatics #deepmind

technology1 month ago•8 min saved

AlphaFold-guided tweaks reduce CRISPR off-target edits while preserving accuracy

Researchers used AlphaFold to map Cas9’s interactions with on- and off-target DNA and pinpoint amino acids responsible for mispairing. By swapping 23 residues at 10 key positions, they produced Cas9 variants with substantially lower off-target editing (down from 28% to 5%) without sacrificing on-target activity, demonstrating a general approach to tailor gene-editing tools and potentially guide broader protein-DNA engineering.

via Ars Technica|

#alphafold #cas9 #crispr

technology2 months ago•3 min saved

AlphaFold Laureate John Jumper Joins Anthropic

John Jumper, Nobel Prize co-winner for AlphaFold with Demis Hassabis, is leaving Google DeepMind to join Anthropic in a move that underscores the ongoing talent shift toward AI startups. Jumper led AlphaFold, the protein-folding AI that now provides hundreds of millions of predicted structures and has accelerated biomedical research; Hassabis praised the lasting legacy of his work. Jumper says he’s taking time to recharge and has not yet disclosed his exact role at Anthropic amid a broader wave of top researchers moving to AI firms ahead of IPOs.

via Business Insider|

#ai-startups #alphafold #anthropic

technology3 months ago•2 min saved

Vertu's AlphaFold: Hermes AI Luxury Foldable Priced from $6,880

Vertu unveils AlphaFold, its first book-style foldable that uses an on-device Hermes AI agent to review documents, orchestrate 70+ apps, and run dashboards, with 24/7 concierge service and satellite connectivity. Available in ultra-premium materials (leather, alligator, gold and diamonds) at prices from about $6,880 up to $34,200, plus security features like an A5 chip and human-approval safeguards. The device pairs premium hardware (65W fast charging, 6,500mAh battery, three rear cameras) with a titanium/liquid-metal hinge and optional luxury finishes, and is now purchasable after its initial preorder.

via GSMArena.com|

#alphafold #foldable #hermes-ai

biotechnology3 months ago•6 min saved

Open-source AI atlas maps 1.1B protein structures, widening the protein universe

An open-access atlas called the ESM Atlas, generated with the ESMFold2 AI model, predicts about 1.1 billion protein structures and 6.8 billion sequences, outperforming AlphaFold in scale and openness and enabling new biology discoveries through a freely available resource.

via Nature|

#ai-in-biology #alphafold #bioinformatics

column3 months ago•60 min saved

AI’s cure-all dream meets the reality of scientific progress

A Verge columnist argues that Demis Hassabis’ claim to 'solve all diseases' at Google I/O needs context: AI like Gemini for Science and AlphaFold can speed research, but real breakthroughs require long timelines, robust validation, and careful communication to avoid hype and misinformation.

via The Verge|

#ai-health #alphafold #column

science4 months ago•45 min saved

Designing life from first principles: the coming era of de novo protein engineering

Nature’s review surveys the state of de novo protein design, outlining a shift from random screening to intentional computational design powered by deep-learning tools (RFdiffusion) and robust structure prediction (AlphaFold), with progress in novel folds, symmetric assemblies, and high-affinity binders as well as enzymes and small-molecule binders. It also notes ongoing challenges in catalysis, switches, and nanomachines, emphasizing that open-source methods like RFdiffusion and ProteinMPNN, together with accurate predictors, now enable broad exploration of design space. The outlook is optimistic: over the next five to ten years we may see sophisticated protein nanomachines and materials with wide applications in medicine, technology and sustainability, driven by where to design rather than how to design.

via Nature|

#alphafold #denovo-protein-design #diffusion-models

technology5 months ago•6 min saved

AlphaFold’s database adds protein pairs to map how molecules work together

AlphaFold’s database now includes 1.7 million predicted homodimer protein complexes, expanding its 200 million monomer structures to show how two copies of the same protein interact. The complex predictions were produced by a international consortium and are freely accessible via EMBL-EBI, broadening the resource’s biological and medical relevance across 20 studied species.

via Nature|

#alphafold #bioinformatics #homodimer

science8 months ago•7 min saved

AlphaFold's Five-Year Evolution Continues to Transform Science

AlphaFold, developed by DeepMind, has revolutionized biology by accurately predicting protein structures, earning a Nobel Prize and expanding into DNA, RNA, and drug interactions, with ongoing advancements aimed at understanding cellular systems and improving medicine.

via WIRED|

#ai-in-science #alphafold #biotechnology

health-and-technology1 year ago•2 min saved

Google DeepMind Prepares for First Human Trials of AI-Designed Drugs

Google DeepMind's affiliate, Isomorphic Labs, is preparing to begin human trials of AI-designed drugs, aiming to revolutionize drug development by increasing success rates and reducing costs, leveraging breakthroughs like AlphaFold for protein modeling.

via Fortune|

#ai-drug-discovery #alphafold #clinical-trials