Tag

Alphafold

All articles tagged with #alphafold

science-and-technology19 days ago•3 min saved

AlphaFold Database Expands to Cover Viral Protein Complexes for Pandemic Preparedness

The AlphaFold Protein Structure Database has added over 8,000 predicted structures for viral protein dimers, covering 23 virus families that infect humans. This expansion, part of a new pandemic preparedness portal, aims to provide researchers with 3D models of viral interactions to accelerate drug and vaccine development. The initiative involved global collaborations, including Nvidia and Google DeepMind, and addresses a previous gap in the database where viral proteins were often poorly represented due to complex genetic sequences.

via Nature|

#alphafold #nvidia #pandemic-preparedness

science-and-technology29 days ago•5 min saved

Pharma Consortium’s Secret Data Boosts AI Protein Models

A consortium of pharmaceutical companies demonstrated that training AI models on proprietary protein data significantly outperforms models using only public datasets. By fine-tuning an open-source version of AlphaFold 3 on over 20,000 private structures, the group achieved higher accuracy in predicting protein-drug interactions. While the results are promising, the model remains private and unpeer-reviewed, highlighting the gap between public data limitations and private industry capabilities.

via Nature|

#ai #alphafold #biotech

science1 month ago•3 min saved

AI-guided discovery: Avl9 acts as an off switch for Arf1, redefining cellular transport and cancer links

Using AlphaFold, Cornell researchers identified Avl9 as an off switch that suppresses Arf1 to regulate intracellular protein trafficking. This reveals a broader DENN-domain–protein system controlling cellular transport, with implications for cancer cell movement and tumor progression, and demonstrates AI’s power to accelerate exploratory biology.

via Cornell Chronicle|

#alphafold #arf1 #avl9

science1 month ago•7 min saved

Molecular atlas of autism points toward targeted therapies

Scientists published the largest map to date of how autism-linked genetic mutations rewire brain protein networks, using AI and lab-grown brain organoids to identify over 1,800 protein–protein interactions (87% new) and prioritize mutations with AlphaFold. The resulting molecular wiring diagram could shift drug development from targeting individual genes to stabilizing disrupted protein complexes, with three therapeutic programs already underway, though translating findings into treatments will take time and may not apply to all autism forms.

via CNN|

#alphafold #autism #drug-discovery

science1 month ago•2 min saved

Autism drug discovery could hinge on protein interaction maps

UCSF researchers built a molecular map linking 100 autism-risk genes to about 1,800 protein interactions, most previously unreported, and used AlphaFold to pinpoint direct connections. They found a FOXP1-FOXP4 interaction that drives autism-like traits in human organoids, suggesting a new drug-discovery blueprint—targeting protein networks rather than genes alone—to identify potential therapies, with potential pathways for industry collaboration.

via Fierce Biotech|

#alphafold #autism #drug-discovery

science2 months ago•6 min saved

GenAI Hallucinations Could Mislead Biotech Discoveries, Researchers Warn

Generative AI can speed up biology research and drug screening, but it can also generate plausible yet false biological signals. Experts say AI outputs should be treated as testable ideas or synthetic data rather than definitive findings, and must be independently verified in real experiments. The risk varies by use, with cases like AlphaFold 3 illustrating how AI errors can distort evidence if not carefully checked.

via ScienceAlert|

#ai-hallucination #alphafold #biology

artificial-intelligence2 months ago•15 min saved

Hassabis Poised to Swap CEO Desk for Scientist Role as Alphabet Reshapes AI Leadership

An anonymously sourced Semafor report says Demis Hassabis has been planning to step down as Google DeepMind CEO for about a year to become Alphabet’s chief scientist, while remaining DeepMind chair and heading Alphabet’s AI drug‑discovery arm Isomorphic Labs. Alphabet confirmed a broader leadership shakeup to sharpen its AI strategy, with Hassabis continuing to influence DeepMind’s and AlphaFold’s ecosystem.

via Gizmodo|

#alphabet-inc #alphafold #artificial-intelligence

technology2 months ago•2 min saved

Google Ditches AlphaFold, Bets Big on Gemini

Google is dismantling the Nobel-winning AlphaFold team, reassigning most researchers to Gemini-focused projects and Alphabet's Isomorphic Labs, with some members leaving for Anthropic, signaling a strategic shift to invest more resources in Gemini and related drug-discovery initiatives.

via Engadget|

#alphafold #deepmind #gemini

technology2 months ago•5 min saved

DeepMind pivots away from AlphaFold to Gemini-powered science AI

Google DeepMind has dismantled the AlphaFold team as it shifts strategy toward Gemini-powered AI to assist and automate scientific discovery, reassigning most AlphaFold researchers to projects in enzyme design, genomics, nuclear fusion and Isomorphic Labs; several core AlphaFold authors have left, including moves to Anthropic, reflecting a broader industry push to frontier AI systems beyond single science challenges.

via Financial Times|

#alphafold #artificial-intelligence #deepmind

science2 months ago•13 min saved

AlphaFold Opens a Free Global Library of Protein Shapes

AI-powered AlphaFold2 transformed protein folding by predicting 3D structures from sequence in minutes, leading to a public database with roughly 214 million predicted protein structures available for free. Most entries are highly accurate or confidently useful, but about a fifth have low confidence and users should filter by pLDDT. The data is CC-BY-4.0 licensed and widely used, enabling rapid research while raising questions about openness for future commercial tools and the handling of multiple conformations and disordered regions. Ongoing updates include isoforms and alignments; methods like AF-Cluster have had mixed results in extracting alternative conformations.

via Space Daily|

#alphafold #bioinformatics #deepmind

technology2 months ago•8 min saved

AlphaFold-guided tweaks reduce CRISPR off-target edits while preserving accuracy

Researchers used AlphaFold to map Cas9’s interactions with on- and off-target DNA and pinpoint amino acids responsible for mispairing. By swapping 23 residues at 10 key positions, they produced Cas9 variants with substantially lower off-target editing (down from 28% to 5%) without sacrificing on-target activity, demonstrating a general approach to tailor gene-editing tools and potentially guide broader protein-DNA engineering.

via Ars Technica|

#alphafold #cas9 #crispr

technology3 months ago•3 min saved

AlphaFold Laureate John Jumper Joins Anthropic

John Jumper, Nobel Prize co-winner for AlphaFold with Demis Hassabis, is leaving Google DeepMind to join Anthropic in a move that underscores the ongoing talent shift toward AI startups. Jumper led AlphaFold, the protein-folding AI that now provides hundreds of millions of predicted structures and has accelerated biomedical research; Hassabis praised the lasting legacy of his work. Jumper says he’s taking time to recharge and has not yet disclosed his exact role at Anthropic amid a broader wave of top researchers moving to AI firms ahead of IPOs.

via Business Insider|

#ai-startups #alphafold #anthropic

technology4 months ago•2 min saved

Vertu's AlphaFold: Hermes AI Luxury Foldable Priced from $6,880

Vertu unveils AlphaFold, its first book-style foldable that uses an on-device Hermes AI agent to review documents, orchestrate 70+ apps, and run dashboards, with 24/7 concierge service and satellite connectivity. Available in ultra-premium materials (leather, alligator, gold and diamonds) at prices from about $6,880 up to $34,200, plus security features like an A5 chip and human-approval safeguards. The device pairs premium hardware (65W fast charging, 6,500mAh battery, three rear cameras) with a titanium/liquid-metal hinge and optional luxury finishes, and is now purchasable after its initial preorder.

via GSMArena.com|

#alphafold #foldable #hermes-ai

biotechnology4 months ago•6 min saved

Open-source AI atlas maps 1.1B protein structures, widening the protein universe

An open-access atlas called the ESM Atlas, generated with the ESMFold2 AI model, predicts about 1.1 billion protein structures and 6.8 billion sequences, outperforming AlphaFold in scale and openness and enabling new biology discoveries through a freely available resource.

via Nature|

#ai-in-biology #alphafold #bioinformatics

column4 months ago•60 min saved

AI’s cure-all dream meets the reality of scientific progress

A Verge columnist argues that Demis Hassabis’ claim to 'solve all diseases' at Google I/O needs context: AI like Gemini for Science and AlphaFold can speed research, but real breakthroughs require long timelines, robust validation, and careful communication to avoid hype and misinformation.

via The Verge|

#ai-health #alphafold #column