tldrdailynews.com logo

Cape Town researchers decode how cancer retools MUC1’s sugar cloak to dodge immunity

1 min read
Source: The Conversation
Cape Town researchers decode how cancer retools MUC1’s sugar cloak to dodge immunity
Photo: The Conversation
TL;DR

South African scientists at the University of Cape Town decoded how cancer rewires MUC1’s sugar coat, shifting from a protective shield to a cloak that blunts immune detection. By recreating the process in vitro and using quantum chemistry, they show tumor enzymes relocate from the Golgi to the endoplasmic reticulum to create aberrant Tn/sTn sugars, shaping a tumor-promoting microenvironment. Mapping this sugar code could inform cancer vaccines, biomarkers and therapies, pushing towards precision medicine.

Topics:healthscience#cancer#glycosylation#immune-evasion#mucin-1#science#synthetic-biology
Share this article
  1. South African scientists make breakthrough in decoding cancer’s most effective survival strategy  The Conversation
  2. Killing cancer requires immune cells to infiltrate tumors' hostile microenvironment—sugar shields can help them break in  Medical Xpress
  3. Killing Cancer Requires Immune Cells To Infiltrate Tumours' Hostile Microenvironment - Sugar Shields Can Help Them Break In  NDTV

Want the full story? Read the original reporting

Read on The Conversation