Five psychedelics converge on a common brain pattern, despite different chemistries

A multi-dataset analysis of over 500 brain scans from 267 participants shows psilocybin, LSD, mescaline, DMT, and ayahuasca produce a shared brain-state: weakened within-network connections and increased cross-network communication. This common neural signature could help standardize psychedelic research and guide future mental-health therapies, though the study used healthy adults and variations across datasets mean more work is needed.