One-Dose Rapamycin Triggers Rapid Reversal of Autism-Like Brain Activity in Adult Mice

A single dose of rapamycin given to adult mice exposed to maternal inflammation reverses most autism-like brain and behavioral changes within about two hours by rapidly normalizing neural activity and network patterns, likely through dampening mTOR signaling and restoring excitation–inhibition balance. The effects are fast but temporary and do not repair underlying structural brain changes; long-term use carries toxicity risks, but the findings point to new targets such as sensory circuit modulation rather than rapamycin itself.