Post-thrombectomy drug enhances stroke recovery by clearing downstream brain vessels

A 14-hospital Spanish trial (CHOICE-2) tested delivering a low-dose alteplase directly into the brain after thrombectomy and found that treating tiny downstream vessels improved 90-day functional outcomes and reduced low-blood-flow patches, suggesting that simply reopening the main artery isn’t enough and that post-procedure alteplase could extend the recovery window, though safety signals require further study.