Glymphatic System Dysfunction Linked to ME/CFS, Australian Study Suggests

Australian researchers report preliminary MRI-based evidence that ME/CFS patients have reduced glymphatic (brain-waste clearance) function, detected with a non-invasive diffusion MRI approach and most evident in the brain's right hemisphere; the findings, published in Frontiers in Neuroscience, link sleep problems and cognitive symptoms to impaired brain clearance and suggest a potential non-invasive path toward diagnosis and treatment—though the study is small and further research is needed.