Ancient cellular map reveals hidden human disease genes
TL;DR Summary
UT Austin researchers reconstructed the last eukaryotic common ancestor’s protein interactome, building the most detailed map of ancient cellular machinery to predict human disease genes and explain links to ciliopathies, kidney disease and osteopetrosis, offering a new approach to interpreting rare variants and guiding disease mechanisms.
- Scientists identify hundreds of ancient genes associated with human diseases The Brighter Side of News
- Reconstructed 1.5‑billion‑year‑old protein network reveals hundreds of hidden disease‑linked genes Phys.org
- LECA reconstruction (IMAGE) EurekAlert!
- Scientists Identify Disease Genes Through Reconstruction of Ancestor to All Complex Life Bioengineer.org
- LECA tree (IMAGE) EurekAlert!
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