Pangenomes Uncover Global Diversity and Divergence in Duplicated Genes
TL;DR
The article introduces ctyper, a new method for genotyping sequence-resolved copy number variations using pangenomes, revealing significant paralog-specific diversity and expression differences across human populations, and demonstrating its accuracy and efficiency in large-scale analyses.
Topics:technologygenetics#copy-number-variation#gene-expression-divergence#genetics#genotyping#pangenomes#paralog-specific-diversity
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