Unraveling the Immune Evasion and Genetic Drivers in Colorectal Cancer Progression
TL;DR
The study reveals that TGF-β creates a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages, contributing to immune evasion and tumor progression.
Topics:top-newscancer-research#cancer-research#colorectal-cancer#immune-evasion#macrophages#t-cell-recruitment#tgf-b
- TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1 Nature
- Epigenetically driven and early immune evasion in colorectal cancer evolution Nature
- How colorectal cancer evades immunotherapy using a dual barrier Medical Xpress
- Scientists pinpoint bowel cancer's 'Big Bang' moment - it could revolutionise life-saving treatment MSN
- Early Genetic Mutations Identified as Key Drivers in Bowel Cancer Progression geneonline.com
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