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Cancer Research

All articles tagged with #cancer research

health1 day ago

Mayo Clinic Study Links Pre-Treatment Gut Microbes to Cancer Survival and Chemo Side Effects

A large-scale study by Mayo Clinic researchers, published in Cell, identifies distinct gut bacterial signatures in 1,364 cancer patients that correlate with specific cancer types, survival rates, and chemotherapy side effects. The findings suggest that pre-treatment microbiome profiles may predict outcomes, particularly for colorectal and breast cancers in younger adults, and link specific bacteria to diarrhea caused by the drug 5-fluorouracil.

via SciTechDaily|
#cancer-research#chemotherapy#early-onset-cancer
NIH Cancer Initiative Sparks 14% Jump in Moderna Shares
biotech2 days ago

NIH Cancer Initiative Sparks 14% Jump in Moderna Shares

Moderna shares surged over 14% on October 9, 2026, after reports that the National Institutes of Health (NIH) will launch a major public-private cancer research initiative in December. The program aims to accelerate treatments for pancreatic, liver, and colorectal cancers, as well as pediatric tumors, leveraging advances in AI and mRNA technology. This move follows recent positive clinical trial results for Moderna’s co-developed melanoma therapy, intismeran, which showed improved outcomes when combined with Merck’s Keytruda.

via Yahoo Finance|
#biotech#cancer-research#moderna
Waddington’s Embryonic Landscape Metaphor Gains Experimental Validation
science3 days ago

Waddington’s Embryonic Landscape Metaphor Gains Experimental Validation

Conrad Hal Waddington’s 1950s metaphor of embryonic development as a ball rolling through a landscape of hills and valleys is being confirmed and refined by modern single-cell data. Researchers now map cell states using gene expression, revealing that development is a dynamic process where cells navigate shifting landscapes defined by gene regulatory networks. This framework explains how identical cells differentiate into specific tissues and offers new strategies for regenerative medicine and cancer treatment by steering cells away from malignant states.

via Quanta Magazine|
#cancer-research#developmental-biology#epigenetics
TA Repeats Expose a Structural Weakness in Cancer’s Extrachromosomal DNA
science-and-health6 days ago

TA Repeats Expose a Structural Weakness in Cancer’s Extrachromosomal DNA

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a built-in structural vulnerability in extrachromosomal DNA (ecDNA), a circular genetic material found in roughly one in six human cancers. The study, published in Nature, reveals that repetitive TA sequences in ecDNA are prone to breaking, forcing cancer cells to rely on specific repair proteins to maintain stability. Disrupting these repair mechanisms destabilizes the DNA circles, offering a potential new therapeutic avenue to combat treatment-resistant tumors.

via Nature|
#cancer-research#dna-repair#ecdna
New Science Review: Sex Chromosomes Drive Disease Risk Beyond Hormones
health-and-medicine8 days ago

New Science Review: Sex Chromosomes Drive Disease Risk Beyond Hormones

A new review in Science argues that X and Y chromosomes directly influence immunity, cancer, and aging, independent of sex hormones. Researchers found that loss of the Y chromosome in men is linked to cancer and heart disease, while X chromosome dynamics in women affect brain aging. The study suggests these genetic factors should shape clinical trial design and personalized treatments.

via News-Medical|
#aging#cancer-research#genomics
Mayo Clinic Study Links Distinct Gut Microbiome Signatures to Five Cancer Types and Early-Onset Disease
health11 days ago

Mayo Clinic Study Links Distinct Gut Microbiome Signatures to Five Cancer Types and Early-Onset Disease

Mayo Clinic researchers published a study in Cell analyzing stool samples from 1,364 cancer patients, identifying 341 bacterial species linked to five specific cancer groups. The study found distinct microbiome patterns in adults under 50 with colorectal and breast cancer, including higher lactate levels and specific bacteria like Veillonella parvula. Additionally, pre-treatment gut bacteria levels predicted chemotherapy-induced diarrhea, specifically for 5-fluorouracil, offering a potential biomarker for treatment side effects.

via Newsweek|
#cancer-research#cell-journal#chemotherapy-side-effects
GLP-1 Weight-Loss Drugs May Lower Cancer Recurrence by Boosting Immune Response, Expert Says
health17 days ago

GLP-1 Weight-Loss Drugs May Lower Cancer Recurrence by Boosting Immune Response, Expert Says

The American Association for Cancer Research's 2026 report notes that obesity is a major cancer risk factor, prompting interest in whether GLP-1 drugs like Ozempic and Mounjaro can reduce cancer incidence. While retrospective studies suggest lower cancer risk and higher survival rates for GLP-1 users, evidence remains mixed, with some studies showing increased risks for specific cancers like thyroid cancer. Dr. Sai Yendamuri of Roswell Park Comprehensive Cancer Center suggests these drugs may alter the body's immune response to fight cancer cells, potentially lowering recurrence rates in lung cancer and melanoma. However, randomized clinical trials are lacking, and it remains unclear if benefits stem from weight loss or direct immune effects. Future trials will determine if GLP-1s can serve as a preventive mechanism for cancer.

via New York Post|
#cancer-research#glp-1-drugs#health
AI in Oncology: From Hype to Curated Clinical Tools Amid a Data Tsunami
health-and-technology18 days ago

AI in Oncology: From Hype to Curated Clinical Tools Amid a Data Tsunami

Artificial intelligence is increasingly used in cancer care, but its impact varies from promising detection tools to curated clinical decision support. While big tech promises cures, practical applications focus on managing information overload, with tools like Onqo Health's Easy Oncology gaining traction among oncologists. AI excels in pattern recognition but faces risks of bias and overreliance, necessitating human oversight.

via The Guardian|
#ai-in-healthcare#cancer-research#clinical-decision-support
Baylor Researchers Unveil CS18, a Compound That Reverses Tumor Resistance to Standard Therapies
health-and-medicine20 days ago

Baylor Researchers Unveil CS18, a Compound That Reverses Tumor Resistance to Standard Therapies

Baylor College of Medicine scientists have developed an experimental drug called CS18 that targets a central biological regulator to overcome cancer treatment resistance. By inhibiting the TopBP1 protein, CS18 weakens multiple survival pathways in tumor cells, restoring their sensitivity to existing therapies like osimertinib and PARP inhibitors. Early tests in animal models showed reduced tumor growth with minimal toxicity, suggesting potential for future combination treatments.

via ScienceDaily|
#baylor-college-of-medicine#cancer-research#drug-resistance
Beyond Apoptosis: The Expanding Catalog of Cell Death Mechanisms
science20 days ago

Beyond Apoptosis: The Expanding Catalog of Cell Death Mechanisms

Scientists have identified over 20 new forms of cell death since 1999, moving beyond the traditional binary of necrosis and apoptosis. These distinct mechanisms, such as alkaliptosis and pyroptosis, offer new targets for treating cancer and autoimmune diseases. Research also reveals that cell death is not always irreversible, with some cells capable of recovering from programmed death.

via Nature|
#anastasis#cancer-research#cell-biology
Feline Tumors Reveal Shared Cancer Genes, Boosting Drug Efficacy
science21 days ago

Feline Tumors Reveal Shared Cancer Genes, Boosting Drug Efficacy

A major 2026 study published in Science reveals that cats share critical cancer-driving gene mutations with humans at nearly identical rates, particularly the TP53 gene. By sequencing DNA from nearly 500 feline tumors across 13 cancer types, researchers found that cats are superior models for human oncology compared to mice due to shared environmental exposures. The study identified FBXW7 as a key driver in feline breast cancer, which also affects aggressive human breast cancers, and showed that specific chemotherapy drugs work better against cells with this mutation. Additionally, feline skin cancers showed UV damage signatures similar to human melanomas, reinforcing the 'One Health' approach to treating shared biological challenges.

via A-Z Animals|
#cancer-research#genetics#oncology
AACR Report: Cancer Progress Stalls as Funding Cuts Threaten Research
health25 days ago

AACR Report: Cancer Progress Stalls as Funding Cuts Threaten Research

The American Association for Cancer Research (AACR) released its 2026 progress report, highlighting significant advances in cancer treatment, including 11 new FDA approvals and a 35% drop in mortality since 1991. However, experts warn that the field is at an 'inflection point' due to threatened federal funding. The report calls for $51.3 billion for the NIH and $8 billion for the National Cancer Institute, criticizing the Trump administration for delaying grants and proposing rules that could politicize scientific merit.

via The Washington Post|
#aacr-report#cancer-research#early-onset-cancer