Tag

Cancer Research

All articles tagged with #cancer research

science12 days ago•7 min saved

Paper mills inflate cancer research metrics by doubling citations

A large analysis of 33,159 papers across 20 high‑impact molecular-oncology journals finds papers likely produced by paper mills receive about twice as many citations as genuine papers, often citing other suspect papers and inflating journal impact factors. Using a BERT-based detector on bioscience articles, 12.3% of papers were flagged; Nature Cancer had none; patterns suggest coordinated manipulation and risks for publishers, though some false positives may exist.

via Nature|

#cancer-research #citations #impact-factor

health25 days ago•5 min saved

J&J CEO projects cancer elimination within a decade through immunotherapy breakthroughs

At the WSJ Leadership Institute summit, Johnson & Johnson CEO Joaquin Duato said the company aims to eliminate cancer within 10 years, citing breakthroughs in immunotherapy that have extended remission in multiple myeloma and improved longevity, with AI and biomarkers enabling earlier diagnosis and more personalized treatments. He suggested some cancers could be cured while others become chronic, and noted J&J's acquisitions like Firefly Bio to target difficult mutations, alongside advances such as a melanoma vaccine study by Merck and Moderna that underscores rapid progress in oncology.

via Fox News|

#cancer-cure-timeline #cancer-research #health

health1 month ago•40 min saved

Breakthrough in Pancreatic Cancer Tests the Value of Federal Science Funding

A new drug called daraxonrasib nearly doubles survival for pancreatic cancer patients after initial chemotherapy, marking a significant KRAS-targeted therapy advance and offering hope that this previously “undruggable” cancer can be managed longer. But the piece stresses that decades of federally funded basic science underpinned the discovery and development, and warns that Trump-era efforts to cut or politicize science funding threaten future breakthroughs by weakening the research ecosystem—even as Congress and the courts push back against some funding cuts.

via The Bulwark|

#cancer-research #daraxonrasib #federal-funding

health1 month ago•2 min saved

Hormone combo around surgery may redefine care for high-risk prostate cancer

A phase 3 PROTEUS trial shows that administering two hormone therapies both before and after prostate cancer surgery improves outcomes versus a single hormone therapy in high-risk, early-stage patients, a result that some doctors see as paving the way for a potential new standard of care.

via statnews.com|

#cancer-research #health #hormone-therapy

cancer-research2 months ago•84 min saved

Submucosal fibroblasts drive early oncofetal plasticity at the invasive front in colorectal cancer

The study shows that metastasis-associated oncofetal cell states arise at the very onset of invasion in colorectal cancer and are shaped by interactions with submucosal fibroblasts. Using multiregional organoids, spatial transcriptomics, and organoid–fibroblast co-cultures, it demonstrates that trophocyte-like cancer-associated fibroblasts at the invasive front induce these fetal-like states, establishing that microenvironmental context—not just tumor genetics—dictates when and where oncofetal plasticity first appears. Although common in early cancers, additional bottlenecks such as immune evasion explain why many lesions do not metastasize.

via Nature|

#cancer-associated-fibroblasts #cancer-research #colorectal-cancer

science4 months ago•15 min saved

Pi Day spotlights how pi powers rockets, research, and real-world science

Pi Day honors the constant pi and its pervasive role in science and engineering, from calculating trajectories for spaceflight to modeling cancer research, illustrating how a single number underpins complex work across disciplines.

via AP News|

#cancer-research #mathematics #note-extra-tag-would-be-removed

health4 months ago•22 min saved

High-fat diet accelerates breast cancer growth in lab models

A study published in APL Bioengineering tested four diets (high-insulin, high-glucose, high-ketone, and high-fat) on engineered triple-negative breast cancer tumor models and found the high-fat diet sped up tumor growth and invasion, with increased activity of the enzyme MMP1. Using a plasmalike medium to mimic the body’s nutrient environment, researchers isolated dietary effects on cancer behavior and plan to explore whether diet also influences chemotherapy response in the future; however, these results are from lab models and human relevance remains to be established.

via New York Post|

#breast-cancer #cancer-research #diet

health4 months ago•4 min saved

Tiny Plastics Detected in 9 of 10 Prostate Tumors, NYU Study Finds

A pilot NYU Langone Health study found microplastic particles in 9 of 10 prostate tumor samples, with cancerous tissue averaging about 40 micrograms per gram versus 16 in healthy tissue (roughly 2.5x higher). The team took rigorous contamination precautions, including using nonplastic tools, and analyzed 12 common plastic molecules. While findings raise the possibility that microplastics could influence cancer risk via inflammation, researchers caution that the small sample size requires larger studies to confirm any causal role; results will be presented at the ASCO Genitourinary Cancers Symposium.

via SciTechDaily|

#cancer-research #health #inflammation

health4 months ago•257 min saved

NSMF Blockade Points to New Route in Colorectal Cancer Therapy

South Korean researchers report that silencing NSMF, a regulator of replication stress in colorectal cancer, triggers irreversible aging in cancer cells and slows or halts tumor growth in mouse models, suggesting a potential new therapy that spares healthy tissue. Published in Nucleic Acids Research, the study highlights NSMF as a key driver of cancer cell replication under stress. With rising colorectal cancer rates in younger Americans and calls to lower screening ages, the findings underscore the push for targeted treatments and earlier detection.

via AOL.com|

#cancer-research #colon-cancer #colorectal-cancer

science4 months ago•2 min saved

Cats Mirror Human Breast Cancer, Paving Cross-Species Treatment Paths

A Science study analyzing nearly 500 feline tumors from five countries across 13 cancer types finds genetic similarities with human cancers, notably FBXW7 mutations in feline mammary tumors that mirror aggressive human cases; two chemotherapy drugs show promise against these tumors in cats, suggesting a potential path for new treatments in humans and enabling faster veterinary testing—highlighting cats as a valuable model for cancer biology and shared environmental factors.

via CTV News|

#breast-cancer #cancer-research #cats

science5 months ago•7 min saved

Bacteria-Derived Toxin Halts Colorectal Cancer Growth While Sparing Healthy Tissue

Researchers report that MakA, a toxin from Vibrio cholerae, when delivered systemically, slows colorectal tumor growth in mice by increasing tumor cell death and reshaping the tumor's immune environment, with no observable harm to healthy tissue or organs, suggesting a tumor-targeted anti-cancer strategy that requires further clinical study.

via SciTechDaily|

#bacterial-toxin #cancer-research #colorectal-cancer

health5 months ago•6 min saved

Global Expert Alliance Sets Course to Accelerate Therapeutic Cancer Vaccines

More than 50 leading cancer vaccine researchers convene a two-day global think tank—organized by the Cancer Vaccine Coalition and AACR—to align priorities and accelerate development and access to therapeutic cancer vaccines through practical strategies, AI-driven antigen prediction, and coordinated funding and regulatory pathways, with trials across glioblastoma, melanoma, pancreatic, breast, ovarian and liver cancers and support from HSBC Innovation Banking, Northwest Biotherapeutics, Pfizer, and Anixa Biosciences.

via PR Newswire|

#cancer-research #cancer-vaccines #clinical-trials

science5 months ago•8 min saved

Cancer Gene Pioneer and HIV/AIDS Denialist Dies at 89

Peter H. Duesberg, a celebrated cancer biologist who helped identify the Src oncogene and later argued that HIV does not cause AIDS, died Jan. 13 in Lafayette, California, at 89 from kidney failure. His work shaped early ideas about oncogenes and cancer genetics, but his AIDS-denial advocacy drew sharp criticism for influencing public health policy; he retired in 2022 and is survived by his wife and four children.

via The New York Times|

#cancer-research #duesberg #hiv-aids

science5 months ago•41 min saved

Twenty Years of Cancer Advances Raise U.S. Five-Year Survival to 70%

A 75th American Cancer Society Cancer Statistics report shows the U.S. five-year cancer survival rate has risen to about 70% (7‑in‑10) thanks to earlier detection and new treatments like immune checkpoint therapy and CAR‑T cell therapy. Survival has improved across cancers (breast 92%, melanoma 95%, prostate 98%), with leukemia and non‑Hodgkin lymphoma up ~20% and 18% and pancreatic and liver cancers also rising (to 13% and 22%). Myeloma and lung cancer survival have climbed to 62% and 15–28%, while late-stage survival now averages 35% (up from 17%). The death rate has fallen about 34% since 1991, saving roughly 4.8 million lives by 2023 — achievements driven by diagnosis, screening, and innovative therapies rather than a cure.

via Good News Network|

#cancer-research #cancer-survival #car-t

health6 months ago•8 min saved

Understanding and Preventing Late Cancer Recurrence

Many cancers can recur years after initial treatment due to dormant tumour cells that evade therapy and immune detection, with ongoing research aiming to understand and target these cells to prevent relapse.

via Nature|

#cancer-recurrence #cancer-research #dormant-tumour-cells