All articles tagged with #macrophages
Using intravital two-photon microscopy, researchers watched CD169-expressing macrophages in the skin’s hypodermis engulf live melanoma cells without T or B cells, a finding that depletion of these macrophages worsened tumor growth and that similar macrophage populations were found at human melanoma margins—suggesting a way to turn ‘cold’ tumors ‘hot’ and possibly enhance responses to immune checkpoint inhibitors.
Tokyo University of Science researchers found that combining common plant compounds (menthol, 1,8-cineole, capsaicin, and others) dramatically enhances anti-inflammatory effects in immune cells, amplifying activity hundreds of times by engaging multiple signaling pathways. This suggests everyday foods and potential functional products could better modulate chronic inflammation, though human studies are still needed.
A mouse study found that polystyrene microplastics can accumulate in macrophages and disrupt their ability to engulf dead cells and pathogens, impairing infection clearance in the lungs. While microplastics are detected in many tissues, there is not yet clear evidence of direct human health effects; researchers caution about potential links to inflammation and cardiovascular issues and plan further human studies to assess relevance to human health.
Research shows that aging immune cells, specifically macrophages, can sustain a heightened inflammatory state through a pathway involving GDF3 protein, which may worsen responses to severe infections like sepsis; targeting this pathway could lead to new treatments for age-related inflammatory conditions.
The study reveals that TGF-β creates a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages, contributing to immune evasion and tumor progression.
Researchers at UC San Diego used AI and molecular biology to uncover how a gene called NOD2 influences macrophage behavior in Crohn's disease, revealing that a mutation disrupting the NOD2-girdin interaction leads to chronic inflammation, and paving the way for new treatments.
A study by NYU School of Medicine found that aging skin experiences a decline in capillary-associated macrophages, which impairs microvascular repair. Boosting these macrophages with growth factors in mice improved blood flow and capillary repair, suggesting potential avenues for reversing skin aging, though human applications remain untested.
Researchers at Trinity College Dublin discovered that applying electrical currents to macrophages can reprogram them to reduce inflammation and promote faster healing, offering a promising new approach for treating injuries and inflammatory diseases.
UC San Diego researchers used AI and molecular biology to uncover how the NOD2 gene influences macrophage behavior in Crohn's disease, revealing that mutations disrupt the balance between inflammatory and healing macrophages, which contributes to the disease's development.
Miriam Merad's 20-year research on macrophages, immune cells involved in inflammation and immune response, is challenging traditional cancer treatments focused on T cells, and early clinical data suggest that targeting macrophages could enhance immunotherapy effectiveness and address aging and autoimmune diseases.
UC San Diego researchers used AI and molecular biology to uncover how a mutation in the NOD2 gene disrupts the balance of inflammatory and healing macrophages in Crohn's disease, resolving a 25-year mystery and highlighting potential treatment avenues.
Scientists at Trinity College Dublin discovered that electrical stimulation can reprogram macrophages to reduce inflammation and promote faster tissue repair, opening new therapeutic possibilities for treating various diseases and injuries.
The study investigates how dysregulation of myeloid progenitors contributes to the formation of immunosuppressive macrophages in tumors, using single-cell sequencing techniques to analyze the tumor microenvironment and identify potential therapeutic targets.
Researchers discovered a new type of immune cell in the fat tissue of mice that appears to contribute to age-related chronic inflammation, or inflammageing, with variations observed between sexes and age groups, shedding light on immune system changes during aging.
Scientists from Trinity College Dublin have discovered that electrical stimulation of macrophages can reprogram them to reduce inflammation and promote faster tissue repair, offering a promising new therapeutic approach for various diseases and injuries.