AI designs complete viral genomes, sparking biosafety concerns

Stanford researchers used AI models Evo1 and Evo2 to design complete bacteriophage genomes capable of infecting E. coli, producing 16 viable designs—the first time AI designed entire viral genomes. The work could advance treatments for antibiotic-resistant infections, but it raises urgent biosafety and biosecurity questions about creating new life and potential misuse; researchers say they excluded viruses that infect complex organisms, held experiments in secure labs, and stress safeguards, while experts warn of risks including possible autonomous misbehavior by AI systems.