Tag

Adjuvant

All articles tagged with #adjuvant

health1 month ago•5 min saved

Roche bets on adjuvant promise after giredestrant’s first-line miss

Roche’s oral SERD giredestrant failed to achieve statistical significance in the persevERA first-line trial for HR+/HER2- metastatic breast cancer when combined with palbociclib, but the company remains optimistic about its adjuvant potential and is designing a new CDK4/6–giredestrant study for early-stage disease. Earlier lidERA showed an adjuvant iDFS benefit; OS data are immature. Roche is pursuing ESR1-mutant labeling in second-line work and exploring additional adjuvant combos, with an FDA decision target around late 2026.

via Fierce Biotech|

#adjuvant #breast-cancer #giredestrant

health1 year ago•2 min saved

Vaccines potentially double as a shield against dementia

A study by Oxford University suggests that certain vaccines, particularly those containing the AS01 adjuvant like Shingrix and Arexvy, may reduce the risk of dementia by boosting the immune system and suppressing viruses, with potential implications for new prevention strategies. The research analyzed health records of 430,000 people and found a significant association between vaccination and decreased dementia diagnoses, though further studies are needed to confirm the mechanisms involved.

via Financial Times|

#adjuvant #dementia #health

health2 years ago•2 min saved

Nasal Tract Protection: Promising Accessory Halts Covid Infection

A study led by the University of Michigan and the Icahn School of Medicine at Mount Sinai has found that a nasal vaccine adjuvant, which triggers a stronger immune response, can prevent COVID-19 infection in mice. The adjuvant, combined with a nanoemulsion, enhances the antibody and memory T cell response in the upper respiratory tract, where the virus proliferates. The researchers plan to conduct further studies and explore the adjuvant's potential for a universal flu vaccine.

via ETV Bharat|

#adjuvant #covid-19 #health