Stem-Cell Immune Reset Sparks Long-Term Remission in Two NMO Patients
Two 28-year-old patients with severe neuromyelitis optica achieved relapse-free, treatment-free remission for 15–16 years after allogeneic hematopoietic cell transplantation (donor stem-cell transplant) that rebooted their immune systems; one now leads a normal life and has children, the other reports good quality of life with reduced disability. While the approach shows promise, it carries substantial risk and was performed in carefully selected, treatment-refractory cases; larger studies are needed to confirm safety and determine broader applicability.