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Autoimmune Disease

All articles tagged with #autoimmune disease

Life-changing Sjogren’s drug could reach the NHS after breakthrough trial
health1 month ago

Life-changing Sjogren’s drug could reach the NHS after breakthrough trial

A patient with Sjogren’s syndrome experienced dramatic relief from monthly injections of ianalumab during a clinical trial, with signs of improved saliva production, less dryness and renewed energy. Experts say the therapy targets the underlying immune attack and could become the first targeted Sjogren’s treatment, potentially rolling out on the NHS in coming years. While promising, the drug can have side effects such as occasional low mood, and responses may vary between patients.

via Daily Mail|
#autoimmune-disease#breakthrough-therapy#health
Raynaud Syndrome: What Cold Fingers Really Signal—and How to Manage It
health2 months ago

Raynaud Syndrome: What Cold Fingers Really Signal—and How to Manage It

Raynaud phenomenon occurs when small blood vessels overreact to cold or stress, causing color changes in fingers/toes (blue, white, red) and sometimes ulcers; primary Raynaud is common and usually harmless, while secondary Raynaud can accompany autoimmune diseases and be more severe. Diagnosis uses nailfold capillaroscopy and blood tests; treatments include off-label options like calcium channel blockers and, in severe cases, epoprostenol infusions. Prevention focuses on avoiding triggers, gradual warming, staying warm, stress reduction, and minimizing caffeine, nicotine, and other vasoconstrictors.

via Yale Medicine|
#autoimmune-disease#capillaroscopy#health
Commensal gut bacteria wield secretion systems to tune human immunity
science2 months ago

Commensal gut bacteria wield secretion systems to tune human immunity

A large analysis of healthy human gut bacteria shows that about 80% of Pseudomonadota carry intact type III secretion systems, with over 90% possessing a host-directed secretion system. The researchers built a meta-interactome linking commensal effectors to human proteins, finding effector-target neighborhoods enriched for genetic variation tied to immune and metabolic diseases. Metagenomic data show effector enrichment in Crohn’s disease but depletion in ulcerative colitis. Functionally, commensal effectors can translocate into human cells and modulate NF-κB signaling and cytokine secretion in vitro, suggesting T3SS contribute to microbiome–host communication and may influence health and disease.

via Nature|
#autoimmune-disease#effector-host-interactome#gut-microbiome
Alzheimer’s Reimagined as an Immune-System Brain Disorder
science2 months ago

Alzheimer’s Reimagined as an Immune-System Brain Disorder

The piece argues Alzheimer's may be primarily an autoimmune disorder of the brain rather than just a brain disease, challenging the traditional beta-amyloid focus and the controversial aducanumab approval. It posits beta-amyloid may be part of the brain’s immune response that goes awry, driving dementia, while other theories (mitochondrial dysfunction, infections, metal handling) gain traction. With Alzheimer's affecting tens of millions worldwide, the article calls for new immune- and mechanism-based therapies and directions.

via ScienceAlert|
#alzheimers#autoimmune-disease#beta-amyloid
UK's First MS Patient Trials Groundbreaking 'Gamechanger' Treatment
health5 months ago

UK's First MS Patient Trials Groundbreaking 'Gamechanger' Treatment

A Hertfordshire mother and biology teacher, Emily Henders, has become the first UK patient to receive a pioneering CAR T cell therapy in a clinical trial aimed at treating multiple sclerosis, a disease that causes immune system attacks on nerves. The experimental treatment, which depletes B cells to reset the immune system, offers hope for slowing or halting disease progression and could be a gamechanger if successful.

via BBC|
#autoimmune-disease#car-t-cell-therapy#clinical-trial
Christina Applegate Reveals MS Diagnosis Has Heartbreakingly Affected Her Daughter
health7 months ago

Christina Applegate Reveals MS Diagnosis Has Heartbreakingly Affected Her Daughter

Christina Applegate has opened up about how her MS diagnosis has deeply affected her 14-year-old daughter Sadie, who struggles with seeing her mother’s health decline and missing her previous self. The disease has caused emotional pain for both, with Sadie expressing her longing for her mom before MS, and Christina sharing how her condition has changed their lives and her daughter's perception of her. Despite the challenges, Sadie remains supportive, helping her mom with daily tasks and showing her love.

via BuzzFeed|
#autoimmune-disease#christina-applegate#daughter-sadie