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Bioengineered Chewing Gum

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Bioengineered chewing gum cuts HPV and harmful oral bacteria, while sparing good microbes
health-and-medicine24 days ago

Bioengineered chewing gum cuts HPV and harmful oral bacteria, while sparing good microbes

Researchers developed a bioengineered chewing gum containing antiviral FRIL and the antimicrobial peptide protegrin that, in ex vivo tests on patient saliva, reduced HPV levels by up to 93% and nearly eliminated two cancer-associated bacteria (Pg and Fn) while preserving beneficial oral bacteria. The gum could serve as an affordable adjunct or preventive therapy to current head and neck cancer treatments, potentially lowering infection risk without disturbing the healthy oral microbiome.

Penn researchers develop antiviral chewing gum to curb oral cancer risk
health3 months ago

Penn researchers develop antiviral chewing gum to curb oral cancer risk

Researchers at the University of Pennsylvania have created a bioengineered chewing gum made from hyacinth bean powder that incorporates the antiviral protein FRIL and the antimicrobial peptide protegrin to neutralize viruses and bacteria linked to oral cancers (notably HPV). Early data show the gum can significantly reduce oral HPV viral load (about 93%), and it’s being studied as both a preventive and potential treatment, with HPV clinical trials at Penn Medicine and additional trials for infectious diseases like COVID-19 and influenza; the team envisions an affordable, off-the-shelf prophylactic gum with broader public health benefits, including interest from NASA for health in space.