XunZi: AI Biologist Uncovers Disease-Modifying Targets in Parkinson’s
XunZi, a brain-inspired AI biologist, fuses logical reasoning with multimodal data to autonomously generate de novo therapeutic targets; in Parkinson’s disease it identifies CHK2 and IRAK4 kinases as disease drivers, with Chk2 inhibition rescuing dopaminergic neuron loss and motor deficits in mice, illustrating a new paradigm for translating fragmented biomedical knowledge into therapeutics across diseases including NSCLC.