Brain wiring may cap PTSD talk-therapy gains, study finds
MRI-based study of 136 people with PTSD and 66 trauma-exposed controls found those with PTSD have weaker prefrontal control over the thalamus when challenging negative self-beliefs, predicting less benefit from standard talk therapies; results suggest treating brain wiring first and exploring psychedelics or other approaches, while noting that ongoing trauma exposure and cultural factors affect outcomes.