After certain gut infections, GI troubles can linger and turn into post-infection irritable bowel syndrome (PI-IBS), a subtype of IBS triggered by the infection. Infections like norovirus or cyclosporiasis may lead to ongoing bowel pain and other GI symptoms even after the acute illness has ended.
Scientists are considering the possibility that COVID-19 may be targeting the gut, as surging cases of the virus have been detected in wastewater. Traditionally, COVID-19 infects people through the nose and mouth, but some virologists believe the virus has altered its requirements for entering cells, making it easier to infect the gut. The newly dominant JN.1 variant of COVID-19 is suspected to be more gut-focused, although there is no direct evidence yet. Wastewater surveillance has shown an increase in the virus, and the variant is both more infectious and more able to evade the immune system. However, there is no evidence that it causes more severe illness than other variants.