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Klinefelter Syndrome

All articles tagged with #klinefelter syndrome

health7 days ago•3 min saved

Testosterone Therapy Triggers Psychosis in a Man with Klinefelter Syndrome

A 45-year-old man on testosterone for osteoporosis developed paranoia and hearing voices about a year into therapy; stopping testosterone led to rapid resolution of symptoms, and he was later restarted on testosterone with close monitoring. He was found to have Klinefelter syndrome, which may increase psychiatric risk, underscoring the need for baseline mental-health screening and vigilant monitoring when initiating testosterone, especially in vulnerable patients.

via Gizmodo|

#case-report #health #klinefelter-syndrome

mental-health8 days ago•27 min saved

Testosterone Therapy Linked to Acute Psychosis in Man With Klinefelter Syndrome

A case report describes a 45-year-old man who developed severe psychosis—hallucinations and hearing voices from his body—after a year of injectable testosterone for infertility and osteoporosis. He was later diagnosed with Klinefelter syndrome (XXY). Stopping testosterone and treating with antipsychotics led to recovery, and a cautious reintroduction at a lower dose with close monitoring did not prompt a relapse. The authors emphasize that this is a single case and does not prove causation, but hormone fluctuations may trigger psychiatric crises in vulnerable individuals, underscoring the need for psychiatric screening during hormone therapies.

via PsyPost|

#case-report #hormone-replacement-therapy #klinefelter-syndrome

genetics-and-archaeology2 years ago•37 min saved

"Identification of Turner Syndrome in Ancient Genomes"

A new computational method has been developed to identify chromosomal aneuploidies, including sex chromosome karyotypes and autosomal aneuploidies, in ancient genomes. The method was applied to ancient British data, revealing the oldest known instance of mosaic Turner syndrome, individuals with Klinefelter syndrome, and an individual with 47,XYY syndrome, providing insights into the historical prevalence of these conditions. The study sheds light on the societal treatment of individuals with aneuploidies in ancient societies and highlights the potential for exploring past gender variability and societal perceptions of individuals with disorders of sex development.

via Nature.com|

#ancient-genomes #chromosomal-aneuploidy #genetics-and-archaeology