Blocking Bacterial Signals May Rebalance Mouth Microbes to Fight Gum Disease
Researchers found that interrupting quorum sensing in dental plaque using lactonases can shift the mouth’s microbial balance toward health-associated bacteria and reduce disease-linked microbes, with effects that depend on oxygen levels above and below the gums; this approach aims to preserve a healthy microbiome rather than kill all bacteria and could inform broader dysbiosis-related therapies.